Curriculum vitae Fernando Torres Andón E-mail: [email protected] Curriculum Vitae Personal information Name Fernando Torres Andón Address C/ Agrupación Escolar Nº22 Alfoz (LUGO) SPAIN +34 630 959220 [email protected] Telephone E-mail Nacionality Date of birth Gender Spanish 30/05/1980 Male https://www.researchgate.net/profile/Fernando_Torres_Andon/ Education and training Title of qualification awarded European Ph.D. in Biochemistry and Molecular Biology at “Universidad de Las Palmas de Gran Canaria” (June 2010). Thesis “Evaluation of New Compounds as Potential Antileukemia Agents”. Degree in Pharmacy at “Universidad de Santiago de Compostela” (October 2003). Other titles Master Degree in Bioinformatics by “Universidad Internacional de Andalucía” (October 2010). Diploma of Advance Studies in “Antitumoral Pharmacology In Vitro” by “Universidad de Las Palmas de Gran Canaria” (November 2007). Diploma in Pedagogical Aptitude at “Universidad Alfonso X El Sabio” (July 2007). Diploma in Public Health by “Escuela Nacional de Sanidad” (ENS), “Instituto de Salud Carlos III” (ISCIII), in collaboration with “Escuela de Servicios Sanitarios y Sociales de Canarias” (March 2007). Master Degree Courses “Collection, Preparation and Biological assessment of Drug from Marine and Land Sources” by “Universidad de las Palmas de Gran Canaria” (2004-2006). Prize Extraordinary Ph.D. award for the best Ph.D. Thesis in Health Sciences of the “Universidad de Las Palmas de Gran Canaria” (2010). Página 1/5 - Curriculum vitae de Fernando Torres Andón Curriculum vitae Fernando Torres Andón Work experience E-mail: [email protected] Date Institution Postdoctoral Researcher in Nanotoxicology April 2011 – Present Karolinska Institutet (Stockholm / Sweden) Date Institution Pharmacist September 2010 – November 2010 Chemist (Alfoz / Spain) Date Institution Innovation Technician March 2010-July 2010 “Fundación Universitaria de Las Palmas". Date Institution Research Ph.D. Fellowship by "Gobierno Autónomo de Canarias" (Spain). March 2006 – February 2010 Universidad de Las Palmas de Gran Canaria. Departamento de Bioquímica. Date Institution Scientific researcher collaborator November 2004 – February 2006 Universidad de Las Palmas de Gran Canaria. Departamento de Bioquímica. Date Institution Pharmacist June 2004 – October 2004 Chemist (Alfoz / Spain) Date Institution Erasmus training period November 2003 – June 2004 Università degli Studi di Padova (Italy). Dipartimento di Scienze Farmaceutiche. Date Institution Pharmacist Training March 2003 – September 2003 Complejo Hospitalario Universitario Juan Canalejo (La Coruña/ Spain) Mother Tongue(s) Other language(s) Página 2/5 - Curriculum vitae de Fernando Torres Andón Spanish, Galician English, Italian Curriculum vitae Fernando Torres Andón E-mail: [email protected] Other profesional experiences and participation in courses - “Risk assessment of immunotoxicity for chemicals” by the World Health Organization, at EUROTOX 2012, Stockholm Waterfront Congress Centre. June 17-20, 2012 - “2nd Italian-Swedish Workshop on Health Impacts of Engineered Nanoparticles” at Karolinska Institutet, Stockholm. June 15-16, 2012 - Third Nanosafety Autumn School – “Understanding the Human Health Effects and Environmental Impacts of Engineered Nanomaterials” at Venice, Italy. November 20-25, 2011 - Introduction course for new co-workers at the Institute of Environmental Medicine (IMM), September 12—16, 2011 - FP7-NANOMMUNE Closing Workshop “Understanding Nano-ImmunoInteractions” at City Conference Center at Norra Latin, Stockholm, Sweden. June 17, 2011 - FP7-NANOMMUNE – Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system “Final Consortium Meeting” at Vita Räfven, Karolinska Institutet, Stockholm, Sweden. June 16, 2011 Courses by “Universidad de Las Palmas de Gran Canaria”: - “XIII PhD course in allergology advances and seventh meeting of primary attention-allergology” (10 hours) “Virtual environment in teaching-learning” (30 hours) Courses by Institute of Cancer Research and the “Universidad de Las Palmas de Gran Canaria”: - “Development and Activity of Antitumor Drugs” “Course of proteomics and cancer” (20 hours) (25 hours) Courses by Faculty of Pharmacy “Università degli Studi di Padova”: - “Avanced methodoly in pharmaceutical chemistry” “Homeopathic Medicines” Courses related with business studies: - IV Conference “Business can be you”. “Universidad Miguel Hernández de Elche”. (september 2006). Matematical Methods in Social Sciences, Economy, Finances and Business Administration. “Universidad de Las Palmas de Gran Canaria”. (april 2005). Given Courses “Universidad de las Palmas de Gran Canaria”: - Electrophoresis of proteins (March 2009) - VI Course of protein analysis and nucleic acids: use of mammal cell lines as experimental model in biomedical research (March 2008) Página 3/5 - Curriculum vitae de Fernando Torres Andón Curriculum vitae Fernando Torres Andón Attached documents: E-mail: [email protected] Curriculum vitae Fernando Torres Andón Publications (1) Andón FT, Pazinatto DB, Fadeel B. Research Highlights: Highlights from the latest articles in nanomedicine. Nanomedicine 2012. (2) Andón, F. T.; Fadeel, B. Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials. Accounts of chemical research 2012. (3) Andon, F. T.; Xiao, L.; Song, X.; Kisin, E. R.; Murray, A. R.; Shvedova, A. A.; Mathur, S.; Fadeel, B. Carbon-based nanomaterials trigger interleukin-1β secretion in human macrophages. Toxicology Letters 2012, 211, S203. (4) Kapralov, A. A.; Feng, W. H.; Andon, F. T.; Chambers, B. J.; Klein-Seetharaman, J.; Star, A.; Shvedova, A. A.; Fadeel, B.; Kagan, V. E. Biodegradation of carbon nanotubes by eosinophil peroxidase. Toxicology Letters 2012, 211, S204. (5) Estévez, F.; Quintana, J.; Marrero, M. T.; Negrín, G.; Burmistrova, O.; Estévez, S.; Rubio, S.; Torres, F.; Nicolini, F.; Triana, J. EVALUACIÓN DE FLAVONOIDES SOBRE LA VIABILIDAD Y PROLIFERACIÓN DE LAS CÉLULAS LEUCÉMICAS HUMANAS. Biocáncer 5, 2011 (6) Torres, F.; Quintana, J.; Estévez, F. 5,7,3’-Trihydroxy-3,4’-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway. Mol. Carcinog 2011, 50, 113–122. (7) Torres Andón, F. Evaluación de nuevos compuestos como potenciales agentes antileucémicos. 2011. (8) Torres, F.; Quintana, J.; Estévez, F. 5,7,3’-trihydroxy-3,4’-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway. Mol. Carcinog 2010, 49, 464–475. (9) Triana, J.; Eiroa, J. L.; Ortega, J. J.; León, F.; Brouard, I.; Torres, F.; Quintana, J.; Estévez, F.; Bermejo, J. Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. J. Nat. Prod 2008, 71, 2015–2020. (10) Torres, F.; Quintana, J.; Cabrera, J.; Loro, J. F.; León, F.; Bermejo, J.; Estévez, F. Induction of G2-M phase arrest and apoptosis by alpha-methylene-gamma-butyrolactones in human leukemia cells. Cancer Lett 2008, 269, 139– 147. (11) Torres, F.; Quintana, J.; Díaz, J. G.; Carmona, A. J.; Estévez, F. Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway. Apoptosis 2008, 13, 716–728. (12) Hernández, J. C.; León, F.; Brouard, I.; Torres, F.; Rubio, S.; Quintana, J.; Estévez, F.; Bermejo, J. Synthesis of novel spirostanic saponins and their cytotoxic activity. Bioorg. Med. Chem 2008, 16, 2063–2076. (13) Díaz, J. G.; Carmona, A. J.; Torres, F.; Quintana, J.; Estévez, F.; Herz, W. Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana. Planta Med 2008, 74, 171–174. (14) León, F.; Brouard, I.; Torres, F.; Quintana, J.; Rivera, A.; Estévez, F.; Bermejo, J. A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells. Chem. Biodivers 2008, 5, 120–125. (15) León, F.; Brouard, I.; Rivera, A.; Torres, F.; Rubio, S.; Quintana, J.; Estévez, F.; Bermejo, J. Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells. J. Med. Chem 2006, 49, 5830–5839. Página 4/5 - Curriculum vitae de Fernando Torres Andón Curriculum vitae Fernando Torres Andón E-mail: [email protected] Presentations in Congresses Authors: Alexander A. Kapralov, Weijong H. Feng, Fernando Torres-Andon, Benedict J. Chambers, Judith KleinSeetharaman, Alexander Star, Anna A. Shvedova, Bengt Fadeel and Valerian E. Kagan. Title: BIODEGRADATION OF CARBON NANOTUBES BY EOSINOPHIL PEROXIDASE Congress: Congress of European Societies of Toxicology. EUROTOX 2012. Publication: Toxicology Letters Meeting place: Stockholm, Sweden Date: 17 to 20 June 2012 Authors: Fernando Torres-Andon, Lisong Xiao, Xuefeng Song, Elena R. Kisin, Ashley R. Murray, Anna A. Shvedova, Sanjay Mathur and Bengt Fadeel. Title: CARBON-BASED NANOMATERIALS TRIGGER INTERLEUKIN-1B SECRETION IN MACROPHAGES Congress: Congress of European Societies of Toxicology. EUROTOX 2012. Publication: Toxicology Letters Meeting place: Stockholm, Sweden Date: 17 to 20 June 2012 Authors: F. Torres-Andon, L. Xiao, E. Kisin, A.R. Murray, A. Shvedova, S. Mathur and B. Fadeel. Title: IMMUNE ACTIVATION INDUCED BY CARBON-BASED NANOMATERIALS Congress: Society of Toxicology Annual Meeting & ToxExpo. SOT 2012. Meeting place: San Francisco, California, USA Date: 11 to 15 march 2012 Authors: F. Torres-Andon, L. Xiao, H. Salminen-Mankonen, S. Tuomela, R Autio, R. Lahesmaa, A. Shvedova, S. Mathur and B. Fadeel. Title: IMMUNOTOXICITY ASSESSMENT OF CARBON-BASED NANOMATERIALS Congress: 36th International Conference and Exposition on Advanced Ceramics and Composites. ICACC 2012. Meeting place: Daytona Beach, Florida, USA Date: 22 to 27 january 2012 Authors: Fernando Torres, José Quintana y Francisco Estévez. Title: 3´,5,7-Trihydroxy-3,4´-dimethoxyflavone induces apoptosis by tubulin binding specifically at the colchicine binding site and through the sphingomyelin pathway. Congress: The EMBO Meeting 2010. Meeting place: Barcelona Date: 4 to 7 september 2010 Authors: Fabio Nicolini, Fernando Torres, José Quintana y Francisco Estévez. Title: Induction of G2/M phase arrest and apoptosis by the flavonoid Tamarixetin on human leukaemia cells. Congress: 6th Meeting of the Young Cancer Investigators of the Canary Islands. Meeting place: Las Palmas de Gran Canaria (Spain) Date: 10 to 13 december 2009 Authors: Torres F, Quintana J y Estévez F. Title: THDF is a microtubule inhibitor and a selective apoptosis inducer in leukaemic cells. Congress: XXXII Congress of Spanish Society of Biochemistry and Molecular Biology. Publication: Congress summaries book Meeting place: Oviedo (Spain) Date: 23 to 26 september 2009 Authors: Quintana J, Rubio S, Negrín G, Torres F, Cabrera J, Loro JF, Estévez F. Title: Search of new antitumoral compounds and evaluation of its action mechanism. Congress: Weeks of Science and Innovation in Canary Islands 2008. Meeting place: Las Palmas de Gran Canaria (Spain) Date: 3 to 18 november,2008 Authors: Torres F, Quintana J, Cabrera J, Loro JF, León F, Bermejo J, Estévez F. Title: α-methylene-γ-butyrolactones induce G2-M cell cycle arrest and apoptosis in human leukaemic cell lines. Congress: XII Science week “Antonio González”. Publication: Congress summaries book. Meeting place: La Laguna (Spain) Date: 6 to 10 october, 2008 Authors: Torres F, Quintana J, Estévez F. Title: Signalling pathways triggered by THDF in human leukaemic cell lines. Congress: XXXI Congress of Spanish Society of Biochemistry and Molecular Biology. Publication: Congress summaries book. Meeting place: Bilbao (Spain) Date: 10 to 13 september, 2008 Página 5/5 - Curriculum vitae de Fernando Torres Andón Curriculum vitae Fernando Torres Andón E-mail: [email protected] Authors: Díaz JG, Carmona AJ, Torres F, Quintana J, Estévez F, Herz W. Title: Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana. Congress: XI Science week “Antonio González”. Publication: Congress summaries book. Meeting place: La Laguna (Spain) Date: 1 to 5 october, 2007 Authors: Hernández JC, León F, Brouard I, Torres F, Rubio S, Quintana J, Estévez F, Bermejo J Title: Synthesis of new spirostanic saponins and their citotoxic activity. Congress: XI Science week “Antonio González”. Publication: Congress summaries book. Meeting place: La Laguna (Spain) Date: 1 to 5 october, 2007 Authors: Torres F, Hernández JC, León F, Brouard I, Rubio S, Quintana J, Estévez F, Bermejo J Title: Synthesis and evaluation of saponins on human tumoral cells. Congress: 3rdMeeting of the Young Cancer Investigators of the Canaries & 1st Meeting of the Young Biomedical Investigators of the Macaronesia. Publication: Program and Proceedings of the Congress, Page 53, 2006. Meeting place: La Laguna (Spain) Date: 9 to 11 november, 2006 Authors: Torres F, Quintana J, Díaz JG, Carmona AJ, Estévez F. Title: Apoptosis induction in leukaemia cells by trifolin acetate: MAP quinase role. Congress: X Science week “Antonio González”. Publication: Congress summaries book, page 85. Meeting place: La Laguna (Spain) Date: 2 to 6 october, 2006 Authors: Torres F, Quintana J, Díaz JG, Carmona AJ, Estévez F. Title: Citotoxic effects and apoptosis induction by derived compounds of phenylbenzopyrone. Congress: XXIX Congress of Spanish Society of Biochemistry and Molecular Biology. Publication: Congress summaries book. Meeting place: Elche (Spain) Date: 7 to 10 september, 2006 Authors: Loro JF, Rubio S, Cabrera J, Estévez F, Torres F, Quintana J. Title: Antitumoral Effect of Melatonin on human leukaemia cells HL-60. Congress: X National Congress of Spanish Asociación of Research about Cancer. Publication: Clinical & Translational Oncology Vol 7, Suppl. 7, 34, 2005 Meeting place: Pamplona (Spain) Date: 13 to 16 october, 2005 Authors: Torres F., Cabrera J, Loro JF, Rubio S, Quintana J, León F, Bermejo J, Estévez F. Title: Synthesis and evaluation of compounds with an α-methylene--butyrolactone group as potencial antitumoral compounds. Congress: X National Congress of Spanish Asociación of Research about Cancer. Publication: Clinical & Translational Oncology Vol 7, Suppl. 3, 52, 2005 Meeting place: Pamplona (Spain) Date: 13 to 16 october, 2005 Página 6/5 - Curriculum vitae de Fernando Torres Andón Curriculum vitae Fernando Torres Andón E-mail: [email protected] Participation in Research Projects and Fellowships - FP7-MARINA - “Managing Risks of Nanoparticles”. FP7-NMP-2012-LARGE-4-263215 - FP7-NANOMMUNE – “Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system”. FP7-NMP-SL-2008-214281 - Department of Education and Science of Spain and FEDER. National Plane of Biomedicine. SAF 2004-07928 (20042007) “New antileukemia agents” and “Development of new, safe and effective antileukemia agents” SAF 2007-62536 (2008-2010). - Regional Education, Cultural and Sports Minister. Canaries Government and FEDER. GRUP 2004-44.”THDF evaluation as potential antitumoral agent”. 2007/045. (2009-2011). - Subsidy for equipment and scientific and technological infraestructure. Universities and Research. Resolutions 21 december 2006 and 21 december 2007. - Canarian Institute of Cancer Research. RED PRODNATCANCER- 2008 y 2009. - Canaries Government PhD Fellowship. Resolution 30 december 2005. BOC 7 feb 2006. Stays in Internationally Recognized Centres Centre: Université Paris-Sud XI Place: Châtenay-Malabry Country: France Year: 2008 Duration (weeks): 14 Topic: Mechanisms of resistance to anoikis of human metastatic colon cancer cells. Centre: University of Study of Padova Place: Padova Country: Italy Year: 2003 Duration (weeks): 32 Topic: Learning techniques used in molecular biology (Erasmus student). Página 7/5 - Curriculum vitae de Fernando Torres Andón