2013 ANNUAL REPORT CELL AND DEVELOPMENTAL BIOLOGY Morphogenesis in Drosophila Group Leader Jordi Casanova Research Associates Sofia Araujo Andreu Casali Marc Furriols Postdoctoral Fellows Kyra Campbell Nareg Djabrayan Gaëlle Le Breton Mohammed Mahidur Rahman Research Assistant Nicolás Martín PhD Students Friedemann Linsler Oscar Martorell Alessandro Mineo Arzu Ozturk Delia Ricolo Pablo Jose Barrecheguren Elisenda Buti Lab Technicians Esther Fuentes Maria Yolanda Rivera HIGHLIGHTS We continue to work on the mechanisms that confer migratory capacity and adult progenitor features to cell clusters. In particular, we focus our efforts on the analysis of the Drosophila tracheal system. We have tracked individual cells in a cluster of migrating cells and characterised the features and cytoskeletal organisation of leading and trailing cells respectively. We have shown that FGF signalling in a single tip cell triggers the collective migration of the cell cluster. PUBLICATIONS Babaoğlan AB, Housden BE, Furriols M and Bray SJ. Deadpan contributes to the robustness of the notch response. PLoS One, 8 (9), e75632 (2013) IRB BARCELONA 2013 ANNUAL REPORT Lebreton G and Casanova J. Specification of leading and trailing cell features during collective migration in the Drosophila trachea. Cell Sci, 127 (Pt 2), 465-74 (2014) (published online in 2013) COLLABORATIONS Specific GATA factors as conserved inducers of an endodermal-EMT Eduard Batlle, IRB Barcelona (Barcelona, Spain) PHD THESES Migració i guiatge cel·lular durant el desenvolupament embrionari de Drosophila melanogaster. Contribució de Hedgehog i Patched. Elisenda Butí Barceló (Universitat de Barcelona) Thesis director: Sofia Araujo Honors: Summa Cum Laude RESEARCH PROJECTS Análisis de los mecanismos básicos que regulan la homeostasis de las células madre intestinales adultas de Drosophila y su papel en el desarrollo de tumores Proyectos Investigación Fundamental, BFU2011-23479 Ministerio de Economía y Competitividad (MINECO), 2012-2014 Principal investigator: Andreu Casali Desenvolupament i morfogènesi a Drosophila Grups Recerca Reconeguts, SGR 2009 00343 Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), 2010-2013 Principal investigator: Jordi Casanova Propiedades celulares individuales y organizacion supracelular en la morfogenesis de Drosophila Proyectos Investigación Fundamental, BFU2012- 32115 Ministerio de Economía y Competitividad (MINECO), 2013-2015 Principal investigator: Jordi Casanova