Bibliografía Capítulo 1. La curva de la vitalidad Crimmins, E. M., y H. Beltrán-Sánchez, «Mortality and morbidity trends: is there compression of morbidity?», J Gerontol: Series B, 66, n.º 1 (enero de 2011), pp. 75-86, <https://doi.org/10.1093/ geronb/gbq088>. Freeman, K. S., «U.S. lives: longer but sicker?», Environ Health Perspect, 119, n.º 3 (marzo de 2001), a118, <https://doi.org/10.1289/ ehp.119-a118a>. Fries, J. F., «The compression of morbidity», Ann Acad Med Singap, 12, n.º 3 (julio de 1983), pp. 358-367. Hansen, M., y B. K. Kennedy, «Does Longer Lifespan Mean Longer Healthspan?», Trends Cell Biol, 26, n.º 8 (agosto de 2016), pp. 565-568, <https://doi.org/10.1016/j.tcb.2016.05.002>. «Increasing Healthspan: Prosper and Live Long», EBioMedicine, 2, n.º 11 (7 de noviembre de 2015), 1559, <https://doi.org/10.1016/ j.ebiom.2015.11.015>. 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Capítulo 2. ¿Qué es el envejecimiento? Araujo, C. G., et al., «Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals», British Journal of Sports Medicine, 56 (2022), pp. 975-980. Celis-Morales, C. A., et al., «Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants», BMJ, 361 (8 de mayo de 2018), k1651, <https://doi. org/10.1136/bmj.k1651>. Cooper, R., et al., «Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study», BMJ, 348 (29 de abril de 2014), g2219, <https://doi.org/10.1136/bmj. g2219>. Dempsey, P. C., et al., «Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length», Commun Biol, 5, n.º 1 (20 de abril de 2022), 381, <https: //doi.org/10.1038/s42003-022-03323-x>. Dykiert, Dominika, et al., «Predicting Mortality From Human Faces», Psychosomatic Medicine 74, n.º 6 (julio-agosto de 2012), pp. 560-566. 2 VIVE MÁS Vive mas BIBLIO-v3.indd 2 25/7/23 10:26 Franceschi, C., et al., «The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates», Front Med, 5 (12 de marzo de 2018), 61, <https://doi.org/10.3389/fmed. 2018.00061>. Franzago, M., et al., «The epigenetic aging, obesity, and lifestyle», Front Cell Dev Biol, 10 (13 de septiembre de 2022), 985274, <https://doi.org/10.3389/fcell.2022.985274>. Gunn, David A., et al., «Facial Appearance Reflects Human Familial Longevity and Cardiovascular Disease Risk in Healthy Individuals», The Journals of Gerontology: Series A, 68, n.º 2 (febrero de 2013), pp. 145-152. —, «Mortality is Written on the Face», The Journals of Gerontology: Series A, 71, n.º 1 (enero de 2016), pp. 72-77. Guyuron, Bahman, et al., «Factors Contributing to the Facial Aging of Identical Twins», Plastic and Reconstructive Surgery, 123, n.º 4 (abril de 2009), pp. 1321-1331, <https://doi.org/10.1097/ PRS. 0b013e31819c4d42>. Huemer, M. T., et al., «Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points», Age Ageing, 52, n.º 1 (23 de enero de 2023), afac324, <https://doi.org/10.1093/ageing/ afac324>. Jackson, S. H., M. R. Weale y R. A. Weale, «Biological age–what is it and can it be measured?», Arch Gerontol Geriatr, 36, n.º 2 (marzo-abril de 2003), pp. 103-115, <https://doi.org/10.1016/ s0167-4943(02)00060-2>. Keshavarz, M., et al. «What it is and how to measure it», Mech Ageing Dev, 213 (9 de junio de 2023), 111837, <https://doi.org/10.1016/j.mad.2023.111837>. Kong, Lijie, et al., «Genetic Evidence for Causal Effects of Socioeconomic, Lifestyle, and Cardiometabolic Factors on Epigenetic-Age Acceleration», The Journals of Gerontology: Series A, 78, Bibliografía 3 Vive mas BIBLIO-v3.indd 3 25/7/23 10:26 n.º 7 (8 de julio de 2023), pp. 1083-1091, <https://doi.org/10.1093/ gerona/glad078>. Li, A., Z. Koch y T. Ideker, «Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging», J Intern Med, 292, n.º 5 (noviembre de 2022), pp. 733-744, <https://doi. org/10.1111/joim.13533>. Lohman, T., et al., «Predictors of Biological Age: The Implications for Wellness and Aging Research», Gerontol Geriatr Med, 7 (26 de septiembre de 2021), <https://doi.org/10.1177/233372142 11046419>. López-González. A. A., et al., «Effectiveness of the Heart Age tool for improving modifiable cardiovascular risk factors in a Southern European population: a randomized trial», Eur J Prev Cardiol, 22, n.º 3 (marzo de 2015), pp. 389-396, <https://doi.org/ 10.1177/2047487313518479>. Lu, A. T., et al., « DNA methylation GrimAge strongly predicts lifespan and healthspan», Aging (Albany NY), 11, n.º 2 (21 de enero de 2019), pp. 303-327, <https://doi.org/10.18632/aging. 101684>. McCrory, Cathal, et al., «GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality», The Journals of Gerontology: Series A, 76, n.º 5 (mayo de 2021), pp. 741-749, <https://doi.org/10.1093/gerona /glaa286>. Mekić, Selma, et al., «Younger facial looks are associate with a lower likelihood of several age-related morbidities in the middle-aged to elderly», British Journal of Dermatology, 188, n.º 3 (marzo de 2023), pp. 390-395. Ortega, F. B., et al., «Muscular strength in male adolescents and premature death: cohort study of one million participants», BMJ, 345 (20 de noviembre de 2012), e7279, <https://doi.org/10.1136/ bmj.e7279>. 4 VIVE MÁS Vive mas BIBLIO-v3.indd 4 25/7/23 10:26 Rasmussen, L. J. H., et al., «Association of Neurocognitive and Physical Function With Gait Speed in Midlife», JAMA Netw Open, 2, n.º 10 (2 de octubre de 2019), e1913123, <https://doi.org/ 10.1001/jamanetworkopen.2019.13123>. Rippon, I., y A. Steptoe, «Feeling Old vs Being Old: Associations Between Self-perceived Age and Mortality», JAMA Intern Med, 175, n.º 2 (2015), pp. 307-309, <https://doi.org/10.1001/jamainternmed.2014.6580>. Saborido, Cristian y Pablo García-Barranquero, «Is Aging a Disease? The Theoretical Definition of Aging in the Light of the Philosophy of Medicine», The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 47, n.º 6 (diciembre de 2022), pp. 770-783. Shklovskii, B. I., «A simple derivation of the Gompertz law for human mortality», Theory Biosci, 123, n.º 4 (abril de 2005), pp. 431433, <https://doi.org/10.1016/j.thbio.2005.01.001>. Siebert, S., et al., «Stem cell differentiation trajectories in Hydra resolved at single-cell resolution», Science, 365, n.º 6451 (26 de julio de 2019), eaav9314, <https://doi.org/10.1126/science.aav 9314>. Studenski, S., et al., «Gait Speed and Survival in Older Adults», JAMA, 305, n.º 1 (5 de enero de 2011), pp. 50-58, <https://doi. org/10.1001/jama.2010.1923>. White, D. K., et al., «Trajectories of gait speed predict mortality in well-functioning older adults: the Health, Aging and Body Composition study», J Gerontol A Biol Sci Med Sci, 68, n.º 4 (abril de 2013), pp. 456-464, <https://doi.org/10.1093/gerona/gls197>. Yang, J., et al., «Association Between Push-up Exercise Capacity and Future Cardiovascular Events Among Active Adult Men», JAMA Netw Open, 2, n.º 2 (1 de febrero de 2019), e188341, <https: //doi.org/10.1001/jamanetworkopen.2018.8341>. Bibliografía 5 Vive mas BIBLIO-v3.indd 5 25/7/23 10:26 Capítulo 3. El origen del envejecimiento Bin-Jumah, M. N., et al., «Genes and Longevity of Lifespan», Int J Mol Sci, 23, n.º 3 (28 de enero de 2022), 1499, <https://doi. org/10.3390/ijms23031499>. Caruso, C., et al., «How Important Are Genes to Achieve Longevity?», Int J Mol Sci, 23, n.º 10 (18 de mayo de 2022), 5635, <https:// doi.org/10.3390/ijms23105635>. Fabian, D., y T. Flatt, «The Evolution of Aging», Nature Education Knowledge, 3, n.º 10 (2011), 9, < https://www.nature.com/scitable /knowledge/library/the-evolution-of-aging-23651151/>. Gavrilov, L. A., y N. S. Gavrilova, «Comments on dietary restriction, Okinawa diet and longevity», Gerontology, 58, n.º 3 (2012), pp. 221-223, <https://doi.org/10.1159/000329894>. —, «Late-life mortality is underestimated because of data errors», PLoS Biol, 17, n.º 2 (7 de febrero de 2019), e3000148, <https://doi. org/10.1371/journal.pbio.3000148>. Grabowska, W., E. Sikora y A. Bielak-Zmijewska, «Sirtuins, a promising target in slowing down the ageing process», Biogerontology, 18, n.º 4 (agosto de 2017), pp. 447-476, <https://doi.org/ 10.1007/s10522-017-9685-9>. Herskind, A. M., et al., «The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900», Hum Genet, 97, n.º 3 (marzo de 1996), pp. 319-323, <https://doi. org/10.1007/BF02185763>. Le Bourg, E., «Evolutionary theories of aging can explain why we age», Interdiscip Top Gerontol, 39 (2014), pp. 8-23, <https://doi. org/10.1159/000358897>. Newman, S. J., «Supercentenarian and remarkable age records exhibit patterns indicative of clerical errors and pension fraud», bioRxiv, 704080 (3 de mayo de 2020), <https://doi.org/10.1101/ 704080>. 6 VIVE MÁS Vive mas BIBLIO-v3.indd 6 25/7/23 10:26 Passarino, G., F. de Rango y A. Montesanto, «Human longevity: Genetics or Lifestyle? It takes two to tango», Immun Ageing, 13 (5 de abril de 2016), 12, <https://doi.org/10.1186/s12979-016-0066-z>. Robinson, A. C., et al., «Influence of APOE Genotype on Mortality and Cognitive Impairment», J Alzheimers Dis Rep, 4, n.º 1 (23 de julio de 2020), pp. 281-286, <https://doi.org/10.3233/ADR200203>. Zhao, Y., y Y. S. Liu, «Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases», Front Cardiovasc Med, 8 (23 de diciembre de 2021), 778674, <https://doi.org/10.3389/fcvm. 2021.778674>. Capítulo 4. Los engranajes del envejecimiento Brandts, L., y P. A. van den Brandt, «Body size, non-occupational physical activity and the chance of reaching longevity in men and women: findings from the Netherlands Cohort Study», J Epidemiol Community Health, 73 (2019), pp. 239-249, <https://doi. org/10.1136/jech-2018-211410>. Chmielewski, P. P., «The association between body height and longevity: evidence from a national population sample», Folia Morphol (27 de enero de 2023), <https://doi.org/10.5603/FM.a2023. 0005>. Di Micco, R., et al., «Cellular senescence in ageing: from mechanisms to therapeutic opportunities», Nat Rev Mol Cell Biol, 22 (2021), pp. 75-95, <https://doi.org/10.1038/s41580-020-00314-w>. Duffy, J. F., K. M. Zitting y E. D. Chinoy, «Aging and Circadian Rhythms», Sleep Med Clin, 10, n.º 4 (diciembre de 2015), pp. 423434, <https://doi.org/10.1016/j.jsmc.2015.08.002>. Ferrucci, L., y E. Fabbri, «Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty», Nat Rev Cardiol, 15, Bibliografía 7 Vive mas BIBLIO-v3.indd 7 25/7/23 10:26 n.º 9 (2018), pp. 505-522, <https://doi.org/10.1038/s41569-0180064-2>. Guo, J., et al., «Aging and aging-related diseases: from molecular mechanisms to interventions and treatments», Sig Transduct Target Ther, 7, n.º 1 (2022), 391, <https://doi.org/10.1038/s41392-02201251-0>. Haycock, P. C., et al., «Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis», BMJ, 349 (8 de julio de 2014), g4227, <https://doi.org/10.1136/bmj. g4227>. Junnila, R. K., et al., «The GH/IGF-1 axis in ageing and longevity», Nat Rev Endocrinol, 9, n.º 6 (junio de 2013), pp. 366-376, <https:// doi.org/10.1038/nrendo.2013.67>. Kacprzyk, J., «Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals», Aging (Albany NY), 13, n.º 6 (21 de marzo de 2021), pp. 7998-8025, <https://doi.org/10.18632/aging.202852>. Kane, A. E., y D. A. Sinclair, «Epigenetic changes during aging and their reprogramming potential», Crit Rev Biochem Mol Biol, 54, n.º 1 (febrero de 2019), pp. 61-83, <https://doi.org/10.1080/10409 238.2019.1570075>. Keshavarz, M., et al., «Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?», Mol Psychiatry, 28, n.º 1 (enero de 2023), pp. 242-255, <https://doi.org/10.1038/ s41380-022-01680-x>. López-Otín, C., et al., «The hallmarks of aging», Cell, 153, n.º 6 (6 de junio de 2013), pp. 1194-1217, <https://doi.org/10.1016/j. cell.2013.05.039>. Oh, J., Y. D. Lee y A. J. Wagers, «Stem cell aging: mechanisms, regulators and therapeutic opportunities», Nat Med, 20, n.º 8 (agosto de 2014), pp. 870-880, <https://doi.org/10.1038/nm.3651>. Rahmani, J., et al., «Association between IGF-1 levels ranges and 8 VIVE MÁS Vive mas BIBLIO-v3.indd 8 25/7/23 10:26 all-cause mortality: A meta-analysis», Aging Cell, 21, n.º 2 (febrero de 2022), e13540, <https://doi.org/10.1111/acel.13540>. Schmauck-Medina, T., et al., «New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary», Aging (Albany NY), 14, n.º 16 (29 de agosto de 2022), pp. 6829-6839, <https://doi.org/ 10.18632/aging.204248>. Sepp, E., et al., «Comparative Analysis of Gut Microbiota in Centenarians and Young People: Impact of Eating Habits and Childhood Living Environment», Front Cell Infect Microbiol, 12 (15 de marzo de 2022), 851404, <https://doi.org/10.3389/fcimb. 2022.851404>. Srivastava, S., «The Mitochondrial Basis of Aging and Age-Related Disorders», Genes (Basel), 8, n.º 12 (19 de diciembre de 2017), 398, <https://doi.org/10.3390/genes8120398>. Capítulo 5. Hormesis: lo que no te mata… te hace vivir más Allen, J. P., M. Nelson y A. Alling, «The legacy of Biosphere 2 for the study of biospherics and closed ecological systems», Adv Space Res, 31, n.º 7 (2003), pp. 1629-1639, <https://doi.org/10.1016/ s0273-1177(03)00103-0>. Bjelakovic, G., et al., «Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis», JAMA, 297, n.º 8 (28 de febrero de 2007), pp. 842-857, <https://doi.org/10.1001/jama.297. 8.842>. —, «Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases», Cochrane Database Syst Rev, 2012, n.º 3 (14 de marzo de 2012), CD 007176, <https://doi.org/10.1002/14651858.CD007176.pub2>. Bibliografía 9 Vive mas BIBLIO-v3.indd 9 25/7/23 10:26 Cardarelli II, J. J., y B. A. Ulsh, «It Is Time to Move Beyond the Linear No-Threshold Theory for Low-Dose Radiation Protection», Dose Response, 16, n.º 3 (1 de julio de 2018), 1559325 818779651, <https://doi.org/10.1177/1559325818779651>. Chen, L., et al., «Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial», J Gerontol A Biol Sci Med Sci, 74, n.º 1 (1 de enero de 2019), pp. 91-98, <https://doi.org/10.1093/gerona/gly223>. Cypess, A. M., y C. R. Kahn, «Brown fat as a therapy for obesity and diabetes», Curr Opin Endocrinol Diabetes Obes, 17, n.º 2 (abril de 2010), pp. 143-149, <https://doi.org/10.1097/MED.0b 013e328337a81f>. David, E., M. Wolfson y V. E. Fraifeld, «Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm», Biogerontology, 22, n.º 2 (abril de 2021), pp. 189-195, <https://doi.org/10.1007/s10522-020-09909-4>. Ghahremani, M., et al., «Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status», Alzheimers Dement (Amst), 15, n.º 1 (1 de marzo de 2023), e12404, <https://doi.org/10.1002/dad2.12404>. Hanssen, M. J., et al., «Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus», Nat Med, 21, n.º 8 (Agosto de 2015), pp. 863-865, <https://doi.org/10.1038/ nm.3891>. Johnson, F., et al., «Could increased time spent in a thermal comfort zone contribute to population increases in obesity?», Obes Rev, 12, n.º 7 (julio de 2011), pp. 543-551, <https://doi.org/ 10.1111/j.1467-789X.2010.00851.x>. Keil, G., E. Cummings y J. 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G., et al., «Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort», J Intern Med, 280, n.º 4 (octubre de 2016), pp. 375-387, <https://doi.org/10.1111/joim.12496>. Liu, J., et al., «Blood donation improves skin aging through the reduction of iron deposits and the increase of TGF-β1 in elderly skin», Mech Ageing Dev, 205 (julio de 2022), 111687, <https://doi. org/10.1016/j.mad.2022.111687>. McDonald, J. T., et al., «Ionizing radiation activates the Nrf2 antioxidant response», Cancer Res, 70, n.º 21 (1 de noviembre de 2010), pp. 8886-8895, <https://doi.org/10.1158/0008-5472.CAN10-0171>. Miao, D., y D. Goltzman, «Mechanisms of action of vitamin D in delaying aging and preventing disease by inhibiting oxidative stress», Vitam Horm, 121 (2023), pp. 293-318, <https://doi. org/10.1016/bs.vh.2022.09.004>. Oberbaum, M., y C. 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