Subido por Tahia Fernández

Notas sobre MRGPRX2

Subramanian H, Gupta K, Ali H. Roles of Mas-related G protein-coupled receptor X2 on
mast cell-mediated host defense, pseudoallergic drug reactions, and chronic
inflammatory diseases. J Allergy Clin Immunol. 2016;138(3):700-710.
For example, while ciprofloxacin and levofloxacin activate MrgprB2 (mice) with EC50 values of
~126 μg/ml and 807 μg/ml, respectively, the same drugs activate MRGPRX2 (human) with
EC50 values of ~6.8 μg/ml and 23 μg/ml.
Porebski Grzegorz, Kwiecien Kamila, Pawica Magdalena, Kwitniewski
Mateusz. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in
Drug Hypersensitivity Reactions. Frontiers in Immunology
2018;9:3027. DOI:10.3389/fimmu.2018.03027
Downstream signaling from MRGPRX2 involves activation of the
phospholipase C-beta pathway, which ends in the release of the
preformed and the de novo synthesized mediators (26, 48).
MRGPRX2-mediated responses seem to be more rapid, but transient in
comparison to IgE-triggered events (33, 48).
Jue Wang, Yongjing Zhang, Chaomei Li, Yuanyuan Ding, Shiling Hu,
Hongli An. Inhibitory function of Shikonin on MRGPRX2-mediated
pseudo-allergic reactions induced by the secretagogue.
Phytomedicine 2020; 68: 153149. Doi:10.1016/j.phymed.2019.153149.