Franc Llorens - Hospital Universitari de Bellvitge

Franc Llorens
DNI: 39884273L
Date of Birth: 05/17/1977
Phone number: 654703038
e-mail: [email protected]
EDUCATION:
2005: PhD Degree in Biochemistry and Molecular Biology obtained in the Universitat Autònoma
de Barcelona (UAB)
2002: DEA Degree in Biochemistry and Molecular Biology obtained in the Universitat Autònoma
de Barcelona (UAB)
1999: B.Sc Degree in Biochemistry obtained in the Universitat Autònoma de Barcelona (UAB)
PROFESSIONAL EXPERIENCE:
Since 2012:
Postdoctoral Researcher:
Bellvitge Biomedical Research Institute (IDIBELL)
Institute of Neuropathology
University Hospital of Bellvitge (HUB)
2008-2011:
Postdoctoral Researcher:
Institute for Bioengineering of Catalonia (IBEC) Barcelona Science Park
Program: Cellular Biotechnology
Unit: Molecular and Cellular Neurobiotechnology
2005-2008:
Postdoctoral Researcher:
Centre for Genomic Regulation (Barcelona Biomedical Research Park)
Program: Bioinformatics and Genomics Program.
Unit: Genomic Analysis of Development and Diseases
2003-2005:
Associated Professor
Department of Biochemistry and Molecular Biology
Universitat Autònoma de Barcelona (UAB)
2000-2005:
PhD:
Department of Biochemistry and Molecular Biology
Universitat Autònoma de Barcelona (UAB)
1998
Practical training
Chemistry Laboratory - Vandellòs Nuclear Power Plant
FELLOWSHIPS AND AWARDS:
2006-2008: Post-Doctoral Fellowship (Juan de la Cierva-Spanish Government)
2000-2003: PhD Fellowship (Generalitat de Catalunya)
PROJECTS:
TITLE: Interacción de la proteína quinasa CK2 con el factor de inicio de la traducción eIF-2 y la
chaperona grp94. Caracterización de las regiones de interacción e importancia funcional en la
respuesta a los factores de estrés. PB98-0856
FUNDING: MCYT
FROM: 1999
TO: 2002
PRINCIPAL INVESTIGATOR: Emilio Itarte
TITLE: Análisis estructural y funcional de la interacción de las proteínas GRP94, eIF-2 y la
proteína quinasa CK2. HI2002-0022
FUNDING: Acción Integrada Hispano-Italiana MCYT
FROM: 2003 TO: 2005
PRINCIPAL INVESTIGATOR: Maria Plana Coll
TITLE: Proteína quinasa CK2 y vía RAF/MEK/ERK: Puntos de interconexión y su contribución a
los efectos biológicos de fármacos antitumorales. SAF2002-03239
FUNDING: MCYT
FROM: 2003 TO: 2006
PRINCIPAL INVESTIGATOR: Emilio Itarte
TITLE: Interacción de la proteína quinasa CK2 con el factor de inicio de la traducción eIF-2 y la
chaperona grp94. Caracterización de las regiones de interacción e importancia funcional en la
respuesta a los factores de estrés. HI2002-0022
FUNDING: Acción Integrada Hispano-Italiana MCYT
FROM: 2001 TO: 2005
PRINCIPAL INVESTIGATOR: Emilio Itarte
TITLE: Grupo de Excelencia. SGR2001-00199
FUNDING: Generalitat de Catalunya
FROM: 2001 TO: 2005
PRINCIPAL INVESTIGATOR: Pere Suau
TITLE: Estudio genómico funcional del gen LRRN6A en la diferenciación neuronal.
Optimización de metodologías experimentales y bioinformáticas para la aplicación de los
microarrays a estudios de expresión. BFU2006-13651
FUNDING: MCYT
FROM: 2005 TO: 2008
PRINCIPAL INVESTIGATOR: Lauro Sumoy
TITULO DEL PROYERCTO: Centro de investigación
neurodegenerativas
FUNDING: CIBERNED
FROM: 2009
TO: 2012
PRINCIPAL INVESTIGATOR: Jose Antonio del Río
en
red
en
enfermedades
TITLE: Grupo de Excelencia. SGR2005-0336
FUNDING: Generalitat de Catalunya
FROM: 2010
TO: 2014
PRINCIPAL INVESTIGATOR: Jose Antonio del Río
TITLE: Caracterización funcional de genes regulados durante la ontogenia del SNC en el
desarrollo cortical y la regeneración axonal. BFU2009-10848
FUNDING: MCYT
FROM: 2010
TO: 2013
PRINCIPAL INVESTIGATOR: Jose Antonio del Río
TITLE: FP7 EUROPEAN GRANT PRIORITY: Protecting the food chain of prions: Shaping
European priorities through basic and applied research. KBBE-2007-2-4-06
Large scale Integrated Collaborative Project
FUNDING: UE (FP7 – Seventh Framework Programme)
FROM: 2009
TO: 2013
PRINCIPAL INVESTIGATOR: Jesús Requena
PUBLICATIONS:
24. Cross-validation of mRNA and miRNA high-throughput expression data
Llorens F#, Hummel M, Sumoy L.
Manuscript in preparation
23. A functional miR-101 isomiR in human brain.
Llorens F#, Bañez-Coronel, Del Río JA, Martí E.
Manuscript in preparation
22. Multiple platform assessment of the EGF dependent microRNAome by microarray and deep
tag sequencing analysis
Llorens F#, Hummel M, Pastor X, Ferrer A, Mattlin H, Vivancos A, Bayés M, Himmelbauer H,
Sumoy L.
Manuscript in preparation
21. Unraveling the neuroprotective mechanisms of PrPc in neurotoxicity
Llorens F#, Del Río JA.
Prion
20. Enhanced proliferation in PrPc-deficient oligodendrocyte precursor cells during development
and in the adult mouse CNS
Bribián A, Fontana F*, Llorens F*, Gavín G, Reina R, Garcia-Verdugo JM, Clemente D, De
Castro F, del Río JA.
PLoS One
19. Neuroprotective role of PrPC to Kainate-induced hippocampal neurotoxicity depends on its
interaction with GluR6/7 and PSD-95 and further JNK3 activation.
Carulla P, Bribian A, Rangel A, Gavín R, Caelles C, del Río, JA. Llorens F#.
Molecular Biology of the Cell, 2011, Jul 14
18. Multiple platform assessment of the EGF dependent transcriptome by microarray and deep
tag sequencing analysis.
Llorens F, Hummel M, Pastor X, Ferrer A et al.
BMC Genomics, 2011, Jun 23; 12:326
17. Emerging functions of myelin associated proteins during development, neuronal plasticity
and neurodegeneration
Llorens F, Gil V, Del Río JA.
FASEB J. 2011, 25(2):463-75 Review
16. Application of massively parallel sequencing to miRNA and IsomiR characterization and
profiling in Huntington disease
Martí E, Bañez-Coronel M, Pantano L, Llorens F, Ferrer I, Estivill X.
Nucleic Acid Research, 2010, 38(20):7219-35
15. Regeneration of Cortical Connections by Gsk3β Inhibition Independently Of Nogo Receptor
1.
Seira O, Gavín R, Gil V, Llorens F, Rangel A, Soriano E, del Río JA.
Journal of Neurochemistry. 2010, 113(6):1644-58
14. Developmental Expression of the Oligodendrocyte Myelin Glycoprotein in the Mouse
Telencephalon.
Gil V, Bichler Z, Lee JK, Seira O, Llorens F, Bribian A, Morales R, Claverol-Tinture E, Soriano
E, Sumoy L, Zheng B, Del Río JA.
Cereb Cortex. 2009 Nov 5
13. Regulation of GABA(A) and Glutamate Receptor Expression, Synaptic Facilitation and
Long-Term Potentiation in the Hippocampus of Prion Mutant Mice.
Rangel A, Madroñal N, Massó AG, Gavín R, Llorens F, Sumoy L, Torres JM, Delgado-García
JM, Río JA.
PLoS One. 2009 4:e7592
12. Developmental analysis of Lingo-1/Lern1 protein expression in the mouse brain: interaction
of its intracellular domain with Myt1l.
Llorens F, Gil V, Iraola S, Carim-Todd L, Martí E, Estivill X, Soriano E, del Rio JA, Sumoy L.
Dev Neurobiol. 2008 68(4):521-41
11. RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential
pathogenic process in neurodegeneration.
Porta S, Serra SA, Huch M, Valverde MA, Llorens F, Estivill X, Arbonés ML, Martí E.
Hum Mol Genet. 2007 May 1;16(9):1039-50.
10. Proteomic analysis of SET-binding proteins.
Vera J, Estanyol JM, Canela N, Llorens F, Agell N, Itarte E, Bachs O, Jaumot M.
Proteomics. 2007 7(4):578-87.
9. Cross talk between protein kinase CK2 and eukaryotic translation initiation factor eIF2beta
subunit.
Llorens F, Sarno S, Sarró E, Duarri A, Roher N, Meggio F, Plana M, Pinna LA, Itarte E.
Mol Cell Biochem. 2005 274(1-2):53-61.
8. The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are
required for its function.
Llorens F#, Duarri A, Sarró E, Roher N, Plana M, Itarte E.
Biochem J. 2006 394(Pt 1):227-36.
7. Unbalanced activation of ERK1/2 and MEK1/2 in apigenin-induced HeLa cell death.
Llorens F, Miró FA, Casañas A, Roher N, Garcia L, Plana M, Gómez N, Itarte E.
Exp Cell Res. 2004 299(1):15-26.
6. Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on
CK2alpha activity.
Llorens F, Roher N, Miró FA, Sarno S, Ruiz FX, Meggio F, Plana M, Pinna LA, Itarte E.
Biochem J. 2003 375(Pt 3):623-31.
5. Persistent nuclear accumulation of protein kinase CK2 during the G1-phase of the cell cycle
does not depend on the ERK1/2 pathway but requires active protein synthesis.
Miro FA, Llorens F, Roher N, Plana M, Gómez N, Itarte E.
Arch Biochem Biophys. 2002 406(2):165-72.
4. PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by
growth factors and oxidative stress.
Garcia L, Garcia F, Llorens F, Unzeta M, Itarte E, Gómez N.
FEBS Lett. 2002 523(1-3):90-4.
3. Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are
unable to induce full differentiation.
Llorens F, Garcia L, Itarte E, Gómez N.
FEBS Lett. 2002 510(3):149-53.
2. The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2
holoenzyme.
Roher N, Sarno S, Miró F, Ruzzene M, Llorens F, Meggio F, Itarte E, Pinna LA, Plana M.
FEBS Lett. 2001 505(1):42-6.
1. The C-terminal domain of human grp94 protects the catalytic subunit of protein kinase CK2
(CK2alpha) against thermal aggregation. Role of disulfide bonds.
Roher N, Miró F, Boldyreff B, Llorens F, Plana M, Issinger OG, Itarte E.
Eur J Biochem. 2001, 268:2, 429-437.
(*) Equal contribution
(#) Corresponding author
INTERNATIONAL MEETINGS:
Authors: Llorens F.
Title: Functional Genomics on prnp models.
Oral communication
Meeting: 2nd Priority Meeting - FP7 – Seventh Framework Programme – UE
Place: Zurich (Switzerland)
Year: 2010.
Authors: Llorens F, Iraola S, Gonzalez E, Mosquera AM, Ferrer A, Pastor X, Miñana B, Lozano
J, Sumoy L.
Title: Multi-platform study to assess expression profiles in HeLa cells in response to growth
factor stimulation with correction for genome dosage effects.
Panel communication
Meeting: 10th Annual Microarray and Gene Expression Data Society (MGED) meeting
Place: Brisbane (Australia)
Year: 2007
Authors: Llorens F, Duarri A, Roher, N, Plana M, Itarte E.
Title: CK2 phosphorylation sites on eIF2beta affect the rate of protein synthesis in HeLa cells.
Panel communication
Meeting: 12th International Conference on Second Messengers and Phosphoproteins.
Place: Montreal (Canada)
Year: 2004
Authors: Llorens F, Miró F, Roher N, García L, Plana M, Gómez N, Itarte, E.
Title: Long term activation of ERK 1/2 by serum or apigenin in HeLa cells lead to different cell
fate.
Panel communication
Meeting: Meeting of the Biochemical Society. Signalling the Future.
Place: Liverpool (UK).
Year: 2002
Authors: Llorens F, Roher N, Plana M, Itarte E.
Title: CK2 interacts with the beta subunit of eukariotic inititaiton factor eiF2
Panel communication
Meeting: 27º FEBS/PABMB Meeting.
Place: Lisboa (Portugal)
Year: 2001
JOURNAL REVIEWER:
Journal Reviewer for: PLoS One
INTERNATIONAL STAYS:
Centre: Beatson Institute for Cancer Research. Glasgow (Scotland)
Year: 2002
Length: 3 months
Pre-Doctoral Stay
Centre: Department of Biological Chemistry, University of Padova. Padova (Italy)
Year: 2005
Length: 2 months
Pre-Doctoral Stay
Centre: Department of Biological Chemistry, University of Padova. Padova (Italy)
Year: 2005
Length: 1 months
Post-Doctoral Stay