CBF Compression Blow Forming for the Pharmaceutical Industry Superior Quality Containers For The Pharmaceutical Industry SUPERIOR NECK QUALITY AND CONSISTENCY Improved CRC features, improved sealing performance, higher consistency and repeatability of all bottle specifications. SUPERIOR CONTAINER PROPERTIES 6,0 5,0 4,0 lower Spec limit upper Spec limit Process distribution 3,0 2,0 1,0 0,0 Superior sustainability and purity due to lower melt temperature. Higher consistency and repeatability of all bottle specifications, delivering the highest performance levels. 100% PERFECT BOTTLES 7,0 mean SUPERIOR PROCESS QUALITY 88 ,5 9 9,51 0 10,5 Weight [g] Normal distribution X ray photo of a bottle Thanks to a fully integrated quality control vision system, CBF ensures full compliance with specifications for all bottles produced. NO GATE Superior performance against stress cracking & improved product appearance. The PHARMA market is experiencing high growth rates worldwide. The main drivers behind this growth are the increasing and progressive aging of the world population, the rising of spending on pharmaceutical and healthcare products and the occurrence of specific chronic diseases. The use of plastic containers is becoming the first choice in many areas in the world for an increasing number of products. Against this backdrop then, SACMI has introduced CBF (Compression Blow Forming) technology for plastic containers capable of responding in the most appropriate way to the needs of this changing market. Superior bottle quality, substantially lower production costs, a fully sustainable process and state of the art technology make CBF your best choice for manufacturing plastic containers. The success of CBF is proven by an increasingly large number of customers who have chosen to rely on SACMI’s technical solutions to enhance their business. Technical content on this innovative process Compression Blow Forming State-of-the-art technology Total cost of the bottle Superior Bottle Quality • Higher efficiency • CBF technology reduces variability, improving tolerances and statistical capability Key process factors CBF (Compression Blow Forming) is a unique combination of compression molding and blow forming. From resin to bottle in one single rotary station: the process begins with the resin being introduced into a continuously operating extruder. The continuous extruder itself provides a constant supply of melted resin which is cut into precisely pre-sized pellets which are then inserted into an open compression mold. This compression cycle molds the preform to have exactly the same weight as the final container. The preform is temperature controlled to provide the best blow process properties. The blow mold is then activated and the preform is blown into the final desired shape without requiring any trimming, thus dramatically reducing scrap. The container is then transferred by a positive control system to the exit conveyor and during this part of the process leak detection as well as visual quality control is carried out on every single container. CBF is a continuous process and allows for maximum machine compactness and fully integrated quality control. From resin to bottle with a single, compact and highly controlled unit: CBF is a game-changing technology for the PHARMACEUTICAL industry. The competitive advantages of an innovative technology • Lower start-up time • Lighter bottle with improved mechanical properties • Reduced labour requirements • Less floor space • Highly repetitive manufacturing process delivering superior consistency • No hot-runner on extrusion system • No gate, no welding lines • Zero resin scrap during production Sustainability • Improved sustainability and purity due to lower melt temperature • Lowest power consumption in the industry • Lower scrap rate during production • Less material wastage during color change find out more about CBF GAME-CHANGING TECHNOLOGY FOR PLASTIC CONTAINERS PROCESS Modular tool One continuous process to manufacture bottles straight from pellets. 4 designed for maximum flexibility 3 Blow Positive control of the bottle Stretch Total quality control performed on each bottle produced 5 Moulding bottle vision system 2 Preform compression 1 Pellet insertion and bottle removal leak test Sacmi product development lab 100% perfect bottles The advantages of a partner with development and testing skills Case studies In the Closures and Containers LAB, the CBF-LAB provides all customers with complete development of pharma packaging solutions, from the initial idea to final testing and start up on the line: Case Study - Summary Data • 3D modelling, rendering and mock up, container prototyping nominal capacity 25 ml • Material and additive testing and characterization (DSC, DMA, crystallinity, viscosity) resin HDPE master white colorant overall weight 5g bottle weight ST. Dev 0.02 g bottle weight range ± 0.06 g bottle height 50 mm bottle diameter 35 mm mean body thickness 0.6 mm top load resistance 80 N max top load resistance > 100 N • Container sizing (optical, CMM, thickness, statistical analysis) • Container performance (mechanical performance, sealing performance, OTR , WVTR) finish Child resistant finish Child resistant finish Child resistant Case Study - Summary Data finish internal seal blown finish OTC foil finish internal seal moulded FINISH SNAP ON nominal capacity 300 ml resin HDPE master white colorant overall weight 24.5 g bottle weight ST. Dev 0.02 g bottle weight range ± 0.06 g bottle height 120 mm bottle diameter 66 mm mean body thickness 0.8 mm top load resistance 200 N max top load resistance > 300 N A wide range of forms Sacmi machines and plants for pharmaceutical containers: know-how and certified solutions The huge potential of CBF The CBF range of machines covers a wide range of products that respond to the demands of today’s PHARMA market. This innovative technology allows producers to manufacture all the most commonly used stock packers and custom bottles while delivering the highest quality standards in the industry. From small pill bottles to the biggest count packers, CBF offers the widest possible freedom in shapes and specs to respond to the most stringent requirements of the PHARMA industry worldwide. CBF offers an ideal solution for container manufacturers who, now more than ever, are looking for the optimum combination of key factors such as output rates and flexibility. Absolute container quality is made possible and guaranteed by the control devices integrated in the machine and is combined with the highest consistency currently available in the industry. CHINA RUSSIA 28 Sacmi Mosca 592 Laeis China Beijing Office Italiansped Laeis (Dalian) Trading Sacmi Imola Moscow Representative Office Sacmi Hong Kong Italiansped GERMANY Sacmi Machinery (Foshan Nanhai) Sacmi Deutschland Sacmi Hong Kong Foshan Commercial Office Sama Maschinenbau Sacmi (Changshu) Machinery Equipment Riedhammer Sacmi (Shanghai) Machinery Equipment Alpha Ceramics Sacmi Machinery (Foshan Nanhai) Zibo Branch Sacmi (Jiajiang) Representative Office Sacmi (Gaoan) Representative Office POLAND LUXEMBOURG 71 Laeis UNITED KINGDOM 22 237 Surface Inspection 13 Sacmi Polska CBF machines offer the best response to market needs while providing breakthrough technology for your PHARMA business. 24 TURKEY Sacmi Istanbul KOREA 2 Sacmi Machinery Korea IRAN 27 Sacmi Iran Sazeh Ceramic & Material Iranian Sacmi Molds & Dies Iran SPAIN Sacmi Iberica 88 50 Sacmi Molds & Dies USA Carle & Montanari USA JAPAN 4 Riedhammer Japan FRANCE EGYPT Sacmi Molds & 4 Dies Egypt NORTH AFRICA Sacmi N.W.C. Africa 2 ITALY Sacmi Imola Sacmi Service Sacmi Forni COSMEC Sacmi Molds & Dies Nuova Sima Keratech Gaiotto IN.TE.SA. Sacmi Carpmec Decodigit Sacmi Filling - Benco Pack Sacmi Verona - Sacmi Labelling Sacmi Packaging Pet Projecta Carle & Montanari - Opm CMFima Iprel Progetti Italiansped Protesa Sacmi Impianti 22 g 11 g 15,5 g Sacmi USA - Hayes PORTUGAL Sacmi Portugal 7 Sacmi West Europe 13 16 g UNITED STATES 2 4 UNITED ARAB EMIRATES Sacmi Middle East 2 VENEZUELA Sacmi Beverage Venezuela BRAZIL 60 Sacmi do Brazil Indústrial e Comércio THAILAND Sacmi Thailand SINGAPORE Sacmi Singapore 19 1531 2 5 VIETNAM Sacmi Vietnam MEXICO Sacmi de Mexico 99 Sacmi Moldes Ceramicos Mexico Sacmi Beverage de Mexico Sacmi de Mexico Division Logistica INDONESIA 47 Sacmi Indonesia PT. Molds & Dies Indonesia SOUTH AFRICA Sacmi South Africa 112 ARGENTINA 2 Sacmi Impianti Argentina INDIA Sacmi Impianti India Sacmi Engineering (India) Sacmi Impianti India Morbi Warehouse CBF technology and products have already been chosen by customers in the biggest pharma markets worldwide: USA, CHINA and INDIA. SACMI is a multinational cooperative and the world-leading designer, builder and distributor of plant engineering solutions in the ceramics, beverage & packaging, food & pharma, automation and service industries. The Group is present in no less than 30 countries and consists of 80 companies. The SACMI network provides advanced after sales service thanks to its far-reaching web of branches and assistance centres, located on all the main markets; there is also an optional Teleservice that can be used with all our plant solutions. The latter ensures simulazione brochure con copertina a tre ante, visualizzazione quando l’anta è chiusa customers can count not only on a fast, efficient spare parts warehouse but also on remote diagnostic services where specialised SACMI technicians work alongside the customer to analyse individual machines and find solutions to any production issues. The Sacmi Group’s technological/market leadership position within its various businesses areas, not to mention the Group’s financial solidity, provides customers with production effectiveness and efficiency they can count on, achievement of expected results and a fast return on investment. simulazione brochure con copertina a tre ante, visualizzazione quando l’anta è aperta The CBF machine range offers the best response to market needs and can handle even the broadest output and/or container volume requirements. The consistency provided by compression guarantees the very best for the final user (greater filling line efficiency). Outstandingly consistent bottle weight allows considerably more accurate tablet filling checks. 14 g 12 g 14,5 g 9,5 g 20 g 15,8 g 10,2 g 14 g 9,5 g 11 g 09/2016 SACMI IMOLA S.C. Via Selice Provinciale, 17/A - 40026 Imola BO Italy Tel. +39 0542 607111 - Fax +39 0542 642354 mail: [email protected] - [email protected] www.sacmi.com Sacmi reserves the right to introduce changes without notice