EXPERIMENTAL ANIMAL MEDICINE

NATIONAL AUTONOMOUS UNIVERSITY OF MEXICO
FACULTY OF VETERINARY MEDICINE
1. COURSE SYLLABUS:
EXPERIMENTAL ANIMAL MEDICINE (0682)
2. SEMESTER:
Tenth
3. CYCLE:
Professional cycle.
4. AREA:
Medicine and Animal Health
5. COURSE TYPE:
Theory (Elective)
6. DURATION:
Hours per week:
Total number of hours:
7. REQUIREMENTS:
Eight weeks
Theory: 4
Theory: 32
0671
8. GENERAL OBJECTIVES:
The student will learn animal experimentation
importance and the responsibility implied in the use of
animals in scientific experiments.
The student will identify the importance of the control of
genetic, environmental, and microbiological variables in
scientific experiments performed on animals.
The student will learn the most important etiological
agents that affect laboratory animals and that interfere
with experimental processes, plus the student will be
able to suggest preventive measurements and control
measurements.
The student will apply quality control principles to
models and scenarios proposed by the teacher, based on
experiences from the teaching-learning process that were
observed during laboratory animal facility visits.
The student will be capable of identifying the main
biological risks that exist in laboratory animal facilities,
and he/she will establish adequate prevention and
protection measurements.
Practice: 0
Practice: 0
9.TEACHING UNITS
9.1 Unit 1 Research and animal experimentation
9.1.1Origins of animal experimentation
9.1.2 Bioethics and animal experimentation
9.2 Unit 2 Laboratory animals and their environment.
9.2.1 Interfering factors that affect the development of experimental research.
9.2.2 Housing and facilities for research animals.
9.2.3 Infection versus disease.
9.2.4 Laboratory animal quality control
9.3 Unit 3 Infection ad diseases.
9.3.1 Importance and classification of infections and diseases according to the way they affect
research.
9.3.2 Prevalence of natural pathogens in commonly used research animal colonies.
9.4 Unit 4 Pathogen agents and diseases of mice.
9.4.1 Parasites.
9.4.2 Bacterial.
9.4.3 Viruses.
9.4.4 Non-infectious diseases.
9.5 Unit 5 Pathogen agents and diseases of rats and gerbils.
9.5.1 Parasites.
9.5.2 Bacterial.
9.5.3 Viruses.
9.5.4 Non-infectious diseases.
9.6 Unit 6 Pathogen agents and diseases of hamsters.
9.6.1 Parasites.
9.6.2 Bacterial.
9.6.3 Viruses.
9.6.4 Non-infectious diseases.
9.7 Unit 7 Pathogen agents and diseases of guinea pigs.
9.7.1 Parasites.
9.7.2 Bacterial.
9.7.3 Viruses.
9.7.4 Non-infectious diseases.
9.8 Unit 8 Pathogen agents and diseases of ferrets, dogs and cats.
8.1 Parasites.
8.2 Bacterial.
8.3 Viruses.
8.4 Non-infectious diseases.
9.9 Unit 9 Research and usage of primates.
9.1 Introduction.
9.2 Uses
9.3 Pathogens and diseases.
9.10 Unit 10 Pain management.
9.10.1 Definition, identification and evaluation.
9.10.2 Relief and pain management.
9.10.3 Anesthesia.
9.10.4 Euthanasia.
9.11 Unit 11 Surgery and animal experimentation
9.11.1 Legislation and ethical principles.
9.11.2 Surgical bases application in animal experimentation.
9.11.3 Possible complications during procedures.
9.11.4 Post operative care.
9.11.5 End point or no return point.
9.12 Unit 12 Biosecurity
9.12.1 Risk assessment and identification of biological, chemical and radiation.
9.12.2 Biosecurity levels in a laboratory animal facility.
10. BASIC BIBLIOGRAPHY
Institute of Laboratory Animal Resources: Guía para el Cuidado y Uso de Animales de Laboratorio.
Edición Mexicana. Academia Nacional de Medicina. México, 1999.
SAGARPA: Norma Oficial Mexicana para la Producción, Cuidado y Uso de los Animales de
Laboratorio. NOM-062-ZOO-1999.
Zúñiga, M.J., Tur, J.A. Milocco, S.N., Piñeiro, G.R. Ciencia y Tecnología en Protección y
Experimentación Animal. Editorial MC Graw Hill –Interamericana, Madrid, España. 2001.
Villanueva, S.O. y Hernández, G.R.: Manual de Ciencia en Animales de Laboratorio. Instituto
Nacional de Ciencias Médicas y Nutrición. SZ, México, 2004.o PA y col. Administración pecuaria
(Aves, Bovinos y Cerdos). México, DF: SUA FMVZ UNAM, 2002.
11. SUPLEMENTARY BIBLIOGRAPHY
Baker, G.D.: Natural Pathogens of Laboratory Animals. ASM Press. Washington, 2003.
Fox, J.G., Anderson, L.C., Loew, F.M., Quimby, F.W., eds. Laboratory Animal Medicine. 2nd
Academic Press, New York, USA, 2002.
Report of the AVMA panel on euthanasia. JAVMA 218 (5):669-696. 2000.
NRC, Nutrient Requirements of Laboratory Animals. 4th rev. ed. NRC (National Research Council).
Nutrient Requirements of Domestic Animal Series. National Academy Press. Washington, D.C.
USA, 1995.
Tena, B. E. Guía de Procedimientos Adecuados Uso y Cuidado de Animales de Laboratorio y
Bioterio. Editada por CIPAM (Comisión Interinstitucional de Prácticas Adecuadas de Manufactura
de la Industria Farmacéutica), México, DF. 1994.
TOPIC
Animal Research
Use and care of laboratory animals
Animal Care Program & Services
UC, Irvine, USA.
Use and care of laboratory animals UK,
Kansas City, USA.
Use and care of laboratory animals UT,
Knoxville, TN, USA.
American Association for Laboratory
Animal Science
International Council for Laboratory
Animal Science
Centro de Información para el Bienestar
Animal, USA.
The Canadian Council on Animal Care
Centro Estudios Avanzados IPN, México.
Fund for the replacement of animals in
medical experiments.
Federation for European Laboratory
Animal Science Associations
12. TEACHING METHODOLOGY
13. COURSE EVALUATION
14. REQUIREMENTS FOR
TEACHING THE COURSE
http://www.sciam.com/index.html
http://www.oiwa.edu/egi-bin/phf.html
http://www.rgs.uci.edu/rig/asvetcon.htm
http://www.ukans.edu/ acu/chapter1.html
http://www.ra.utk.edu/ora/labanimal/ATTENVET.html
http://www.aalas.org
http://www.iclas.org
http://www.awic.org
http://www. ccac.org.ca
http://www. cinvestav.mx
http://www. frame.org.uk
http://www.felasa.org
Exposition by the teacher with questions.
Commented lecture
Guided discussion
Written examination.
Homework.
Reports.
Given the specialization level required for the subjects
of this syllabus, it is required a multidisciplinary team
that involves specialized teachers in Laboratory animal
sciences with a minimal experience of three years.