LAB ANIMALS PRODUCTION MEDICINE.

NATIONAL AUTONOMOUS UNIVERSITY OF MEXICO
FACULTY OF VETERINARY MEDICINE
1. COURSE SYLLABUS:
LAB ANIMALS PRODUCTION MEDICINE
(0671).
2. SEMESTER:
Eighth to ten
3. CYCLE:
Professional
4. AREA:
5. COURSE TYPE:
Animal Health and Medicine, Animal Production
and Economics.
Theory (elective)
6. DURATION:
Hours per week:
Total number of hours:
7. REQUIREMENTS:
8 Weeks
Theory: 4h
Practice:0 h
Theory:32 h
Practice:0 h
All subjects of the intermediate cycle
8. GENERAL OBJECTIVES:
The student will learn ethical principles on
laboratory animal husbandry and their use in
tests, as well as animal testing norms.
The student will appreciate the relevance of
using animal models in biomedical investigation
through their contribution to human health and
will acquire knowledge on its development,
biological features, reproduction and health
status.
The student will understand the impact of having
several variables affecting testing results by
controlling genetics, zoological, nutritional and
environmental factors.
9. TEACHING UNITS
9.1 Unit 1 Historical environment, specialty development and current concept of
laboratory animals.
9.1.1 Historical perspectives and origins of Laboratory Animal Science.
9.1.2 Worldwide and National present situation of the specialty.
9.1.3 Benefits of animal testing for human and animal health.
9.1.4 Spontaneous and induced concept of animal model and its application in biomedical
investigation.
9.1.5 Development and biological characteristics of selected animal models of interest in
biomedical investigation.
9.2. Unit 2 Bioethical principles ruling laboratory animal husbandry, care and
management and their laws.
9.2.1 Bioethical principles ruling animal testing.
9.2.2 3 R's Principle (replace, reduce, refine).
9.2.3 National laws and regulations, Mexican Official Norm.
9.2.4 Supplementary and alternative methods of laboratory animals.
9.3 Unit 3 Taxonomy, laboratory animal origins and use of rodents most used in
investigation.
9.3.1 Relevant anatomic and physiological differences.
9.3.2 Reproductive parameters: Sexual maturity, heat cycle, first service age, gestation,
first delivery age, breastfeeding and weaning.
9.3.3 Coupling and housing methods.
9.4 Unit 4 Basic principles of animal housing, environmental needs of laboratory animals
and their control.
9.4.1 Animal facility classification.
9.4.2 Construction principles.
9.4.3 Characteristics of equipment and various supplies.
9.4.4 Macro and micro environment.
9.4.5 Influence of environmental factors on animal response to testing.
9.5 Unit 5 Genetic variability, its relevance in testing response and its control.
9.5.1 Nomenclature principles.
9.5.2 Concepts about: Colonies, strains and sub strains.
9.5.3 Non blood colonies, lineages, hybrid strains.
9.5.4 Most used strains of blood colonies.
9.6 Unit 6 Influence of microbiological variable on animal health and wellbeing and its
influence in investigation outcomes.
9.6.1 Microbiological variable effect in the quality of investigations and bioethical
coherence.
9.6.2 Animal microbiological classification.
9.6.3 Main zoonosis.
9.6.4 Hygiene and disinfection principles.
9.6.5 Biosafety basic principles.
10. BASIC BIBLIOGRAPHY
1. Institute of Laboratory Animal Resources: Guía para el Cuidado y Uso de Laboratory
animals. Edición Mexicana. Academia Nacional de Medicina. México, 1999.
2. SAGARPA: Norma Oficial Mexicana para la Producción, Cuidado y Uso de los
Laboratory animals. NOM-062-ZOO-1999.
3. Villanueva, S.O. y Hernández, G.R.: Análisis de Costos y su Estimación para
Recursos en Bioterios. Instituto Nacional de Ciencias Médicas y Nutrición. Salvador
Zubirán. México, D.F. 968-6499-43-1. 2004.
4. Zúñiga, M.J., Tur, J.A. Milocco, S.N., Piñeiro, G.R. Ciencia y Tecnología en
Protección y Experimentación Animal. Editorial MC Graw Hill –Interamericana,
Madrid, España. 2001.
11. SUPLEMENTARY BIBLIOGRAPHY
1. Baker, G.D.: Natural Pathogens of Laboratory Animals. ASM Press. Washington,
2003.
2. Fox, J.G., Anderson, L.C., Loew, F.M., Quimby, F.W., eds. Laboratory Animal
Medicine. 2nd Academic Press, New York, USA, ISBN: 0122639510. 2002.
3. Tena, B. E. Guía de Procedimientos Adecuados Uso y Cuidado de Laboratory animals
y Bioterio. Editada por CIPAM (Comisión Interinstitucional de Prácticas Adecuadas
de Manufactura de la Industria Farmacéutica), México, DF. 1994.
4. AVMA. Report of the AVMA Panel on Eutanasia. JAVMA 218(5):669-696, 2000.
5. Laboratory Animal Science. A partir del 2000 como: Comparative Medicine.
Contemporary Topics in Laboratory Animal Science.
Veterinary Pathology.
JAVM.
TOPIC
Investigación Animal.
http://www.sciam.com/index.html
Cuidado y Uso de Animales.
http://www.oiwa.edu/egi-bin/phf.html
Animal Care Program & Services
UC, Irvine, USA.
http://www.rgs.uci.edu/rig/asvetcon.htm
Cuidado y Uso de Animales. UK, Kansas City, USA.
http://www.ukans.edu/
Cuidado y Uso de Animales. UT, Knoxville, TN, USA.
http://www.ra.utk.edu/ora/labanimal/ATTENVET.html
Asociación Profesional, USA.
http://www.aalas.org
Asociación Profesional, Europa.
http://www.iclas.org
Instituto para el Bienestar Animal, USA.
http://www.awic.org
Consejo Canadiense de Cuidado Animal, Canadá.
http://www. ccac.org.ca
Centro Estudios Avanzados IPN, México.
http://www. cinvestav.mx
Asociación Profesional, UK.
http://www. frame.org.uk
Oral presentation of the professor with question
12. TEACHING METHODOLOGY
sessions.
Presentation to the students.
Case study.
Written exams
13. COURSE EVALUATION
Practical reports
Task portfolio
Class participation
Veterinarian with postgraduate studies in the
14. REQUIREMENTS FOR
TEACHING THE COURSE
area or five years experience.