Transportadores de glucosa: GLUT Clase I

Transportadores de glucosa
Sitio de
glicosilación
Sitio de
reconocimiento
de la glucosa
Estructura
general de
un GLUT
Gould, G. W., & Holman, G. D. (1993). The glucose
transporter family: structure, function and tissue
expression. Biochemical Journal., 295, 329-341.
Clasificación de los GLUT
Castrejón, V., Carbó, R., & Martínez, M. (2007). Mecanismos moleculares que intervienen en el transporte de glucosa. Revista de Educación Bioquímica., 26(2), 49-57.
GLUT 1
Aminoácidos
Transporta
Km
492
Glucosa y Galactosa
1.6 mM y 17.0 mM
Crystal structure of
GLUT 1
https://www.ncbi.nlm.nih.gov/Struc
ture/pdb/4PYP
GLUT 2
Membrane topology of glucose
transporter 2 (GLUT2)
Terova, G., Rimoldi, S., Brambilla, F., Gornati, R.,
Bernardini, G., & Saroglia, M. (2009). In vivo regulation of
GLUT2 mRNA in sea bass (Dicentrarchus labrax) in
response to acute and chronic hypoxia. Comparative
Biochemistry and Physiology Part B: Biochemistry and
Molecular Biology, 152(4), 306–316.
Aminoácidos
Transporta
Km
524
Glucosa // Glucosamina
17 mM // 0,8 mM
GLUT 3
Crystal structure
of GLUT 3
Aminoácidos
Transporta
Km
496
Glucosa y Galactosa
2 mM y 8.5 mM
Simpson, I. A., Dwyer, D., Malide, D., Moley,
K. H., Travis, A., & Vannucci, S. J. (2008). The
facilitative glucose transporter GLUT3: 20
years of distinction. American Journal of
Physiology-Endocrinology and Metabolism,
295(2), E242–E253.
GLUT 14
Aminoácidos
Transporta
Km
497
Glucosa
-
Wu, X., & Freeze, H. H. (2002). GLUT14, a Duplicon of GLUT3, Is Specifically Expressed in Testis as Alternative Splice Forms. Genomics, 80(6), 553–557.
Huang, S., & Czech, M. P. (2007). The GLUT4 Glucose
Transporter. Cell Metabolism., 5(4), 237-252.
GLUT 4
Aminoácidos
Transporta
Km
509
Glucosa
5 mM
PI3K-dependent insulin signalling
Leto, D., & Saltiel, A. R. (2012). Regulation of glucose transport by insulin: traffic control
of GLUT. Nature Reviews: Molecular Cell Biology, 13(6), 383-396.
El GLUT 4 y
la insulina
Huang, S., & Czech, M. P. (2007). The GLUT4 Glucose Transporter. Cell Metabolism., 5(4), 237-252.