RpoA - Plos
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dnaA dnaN recF yaaA yaaB gyrB gyrA guaB dacA pdxS pdxT serS tadA yaaC dck dgk abrB 30,000bp 40,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yabG ispE veg sspF purR yabJ spoVG gcaD prs ctc mfd pth yabK spoVT yabM yabN yabP divIC yabO yabQ yabR spoIIE yabS yabT tilS hprT ftsH 70,000bp coaX hslO yacD cysK pabB pabC pabA sul folK dusB folB yazB 80,000bp lysS 90,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 mcsB clpC radA disA yacL ispD ispF gltX cysE cysS rlmB secE nusG rplK rplA mrnC yacP sigH rpmGB rplJ rplLybxB rpoB rpoC 120,000bp rpsL rplGB rpsG fusA 130,000bp tufA ybaC rplB rplC rpsJ rplD rplW rplR rplV rpsQ rplX rplE rpsH rplO rpsS rpsC rplPrpmC rplNA rpsNA rplF rpsErpmD secY infA rpsM adk mapA ybzGrpmJ rpsK rpoA rplQ 140,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His yabE 5.00 110,000bp RpoC-His yabD 0.00 ctsR mcsA RpoA-His metS RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 yaaI 20,000bp 60,000bp Experiment 1 tmk yabB yabC yaaT yabA yazA 5.00 ksgA rnmV Experiment 2 yaaO yaaR yaaQ holB RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 10,000bp yaaH dnaX xpaC csfB yaaN recR bofA yaaK yaaL 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 1 rplQ ybxA ybaE ybaF truA rplMrpsI ybaJ cwlD ybaK salA kbaA gerD ybaR ybaN RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 170,000bp ybbF ybbH murQ 190,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 adaA adaB ndhF ybcC ybcI ybcFybcH ybcL ybzH skfB ybcM skfA skfC skfE skfF skfG skfH ybdG ybdJ ybdK ybzI ybdO ybxG ybdM ybdN ybxH csgA cypC ybxI 220,000bp ybfA ybeF ybeC ybyB glpQ ybfB purT glpT ybfE ybfF 230,000bp ybfG ybfH mpr ybfJ ybfK ybfM pssA psd ybfN ybfO ybfI 240,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ybfP ybfQ ybgA ybgB ilvE nagP nagBB glnJ ybgF ybgG glnT glnL ycbC ycbD gudP gudD ycbG garD ycbJ ycbK rtpA ycbL ycbM ycbN glsA phoD cwlJ ycbR yczK ycbO ycbP 270,000bp 280,000bp tatCD tatAD ycbU pcp ansZ lmrB lmrA estA yccF yczC natA natB natK natR yccK ycdA 290,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His ybbE 5.00 260,000bp RpoA-His ybbD 0.00 gltP RpoC-His ybbC 5.00 ybfO RpoA-His ybbB ybbK ybbJ 0.00 210,000bp Experiment 1 feuA 180,000bp alkA Experiment 2 feuB glmM 5.00 glmS Experiment 1 sigW rsiW ybbP ybbR ybbA feuC 160,000bp Experiment 2 ybaS 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 2 ycdB ycdC ycdA rapJ ycdF ycdG adcA adcC adcB cwlK yceC yceDyceE yceF yceG yceH yceI yceB yceJ mdr ycgI nadE ycgH aroK tmrB 330,000bp ycgK cah ycgL ycgM ycgN ycgO ycgP ycgJ ycgQ 340,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ycgS nasA nasF nasD nasE nasC folEB yckD yckC bglC yciC yciB yczL nasB yckA yckB hxlR nin nucA tlpC srfAA srfAB comS srfAC hxlB hxlA 370,000bp 380,000bp 390,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 srfAD ycxA ycxD ubiX ubiD sfp sfp yczE tcyC tcyB tcyA yclA yclD bsdD yclE yclG dtpT gerKA yczF gerKC gerKB yclJ yclK rapC phrC yczN yczM yclM yclH yclI 420,000bp 430,000bp yclN yclO yclP yclQ yczG ycnB ycnC ycnD ycnE gabR gabT gabD glcU gdh ycnL ycnI ycnJ mtlA ycnK 440,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His amhX ycgE ycgF ycgG 5.00 410,000bp RpoA-His lctP 0.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ldh 5.00 ycxB ycxC Experiment 1 ycgB amyE 0.00 360,000bp Experiment 2 yceK ycgA 5.00 ycgT srfAC opuAB opuAC 320,000bp RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 310,000bp ycgQ ycgR opuAA 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 3 mtlA mtlF mtlD ycsA sipU ycsD ycsE yczH ycsF ycsG ycsI kipI kipA kipR lipC yczO yczI pbpC ycsN mtlR ydaB yczJ RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ydaO mutTydaP ydbA ydzK mntH 480,000bp ydaT ydaS dctS ydbD dctR dctB 490,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 ydbI ydbJ ydbK ydbL ydbM ydbO ddl murF cshA ydbS ydbT ydbP acpS ydcC alrA ndoA rsbT endB rsbRA rsbS rsbU rsbW rsbV sigB rsbX ydcG ydcF ydcH ydcI ydcP ydzL sacV ydcO ydcQ ydcK ydcA ydcL 520,000bp 0.00 ydcR ydcT yddB ydcS yddA yddD yddC yddE yddG yddF yddH yddI yddJ immR immA rapI yddM phrI yddK 530,000bp 540,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yddQ lrpB yddR yddS yddT ydzM ydzN ydeA cspC ydeD ydeB ydeC ydzE ydeF ydeE ydeG ydeH ydeI ydeL ydeJ ydeK ydeM ydeN ydzF ydeO aseR ydeS ydzO ydfA ydeQ ydeP 570,000bp ydeR ydzS ydzS ydfB ydfD ydfC 580,000bp ydfF ydfE ydfH ydfI ydfJ ydzP ydfG ydzQ ydfN ydfO nap ydfK ydfL ydfM ydfP ydfQ ydzH ydzR 590,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His ydaN 5.00 560,000bp RpoA-His ydaM 0.00 yddN RpoC-His ydaL 5.00 lrpA RpoA-His ydaK ydzA 470,000bp 510,000bp Experiment 1 ydaJ 0.00 ydbN Experiment 2 lrpCtopB 5.00 dctR dctP Experiment 1 ydaH ydaC 460,000bp Experiment 2 ydaD ydaEydaF ydaG ydbC gsiBydbB 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 4 ydfS ydfR ydzR ydgD ydgC ydgE ydgB cotPydgA ydgG ydgH vmlR ydgF ydgK dinB ydhC ydhD ydgI ydgJ ydhE ydhB ydhF phoB RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 610,000bp purK pbuE thiL ydiB ydiC rimI gcp ydhU ydhU groES ydiL ydiK ydiF 630,000bp 640,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 groEL groES ydzV ydiM ydzU ydiO ydiP ydiR ydiS ydjA ydjB ydjC ydzW ydzW ydzW ydzW ydzW ydzW ydzW gutB gutP ydjE pspA ydjG ydjH ydjI gutR iolT ydjJ ydjM ydjN yeaB ydjO ydzJ ydjP bdhA 670,000bp yeaA cotA gabP yeaC yeaD yebA guaA pbuG yebC yebE purE yebD yebG purK ydzX 680,000bp 690,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 purB purQ purC purS purL purF purM purN purH purD yecA yerA yezF yerB yerC pcrB pcrA ligA yerH gatA gatC yerI yerD gatB sapB opuE 720,000bp swrC yerO 730,000bp dagK yefA yefC yeeA yeeB yeeC yeeG yezA yeeF yeeD yezG yefB 740,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His gmuG 5.00 710,000bp RpoC-His gmuR gmuE gmuF 0.00 yezC RpoA-His gmuD RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ydhH ydhI ydhK 620,000bp 660,000bp Experiment 1 ydhJ tatCY moaC rex tatAY 5.00 ydzT ydzT ydzT ydzTydzT Experiment 2 ydhG gmuA gmuB gmuC 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5 yeeG rapH yeeI phrH yesL cotJB yesJ yeeKyezE yesE yesF cotJA cotJC yesK yesM yesN yesO yesP yesQ yesR yesS rhgT yesU yesV yesW yesX yesY yesZ yetA lplA lplB lplC lplD yetJ yetI yetI yezD yetK yetF yetG yetH 770,000bp yfnG yfkQ 790,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 yfnF yfnE yfnD yfmT yfmS yfmR yfmQyfmPyfmO yfmN yfnB yfnA yfmL yfmK yfmM yflT yfmA pel yfmG yfmJ yfmI yfmF yfmE yfmD yfmC 0.00 yflS citS citT yflP citM yflN yfmB nosA yflK yflL 820,000bp 830,000bp yflB yflD yflA nagP yflI yflJ yflH mapB yflE yfkT yfkR yfkS yfkQ 840,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 treA treR yfkO yfkM yfkN yfkJ yfkI yfkH yfkL yfkK yfkE yfkF yfkD yfjT pdaA yfkC yfkA yfjP yfjR yfjO yfzA dusC yfjM yfjL acoA acoB yfjQ acoC acoL acoR sspH yfjF yfjE yfjD yfjC 870,000bp 880,000bp malA yfjB malR malP malQ yfiC catDcatE yfiF yfjA 890,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His yetN 0.00 860,000bp RpoC-His yfnG 5.00 treP RpoA-His yfnH RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ltaSA 0.00 810,000bp Experiment 1 yetO 5.00 yfnC Experiment 2 yetL 780,000bp RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 760,000bp yetM 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 6 yfiG yfiH yfiI yfiJ yfiK yfiL yfiM yfiN estB yfiQ padR yfiT yfiR yfiS mprF yfiU yfiZ yfiV ygaFperR yfhS ygaE 930,000bp gsaB ygxA ygzB 940,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 thiC senS ygzC ygaK ssuB ssuA ssuC ssuD ygaN rpsNB yhbA yhbB cspRyhbD yhbE yhbF prkA yhbH yhbIyhbJ yhcA yhcG yhcC yhcE yhcB yhcD yhcF yhcH yhcI yhcJ ygzD ygaO yhzB katA cspB 970,000bp tcyP yhcK yhcN yhcO yhcM 980,000bp yhcR yhcS yhcQ yhcUyhcVyhcW yhcX yhcT 990,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 glpP glpF glpK glpD pgcA yhcY yhcZ yhdA yhdC spoVR nsrR ygxB lytE phoA citA yhdF ctrA yhdH yhdJ citR yhdI 1,020,000bp yhdL yhdK yhdN sigM 1,030,000bp plsC yhdR yhdP cueR yhdY yhdX yhdT yhdZ yhdV crcBA yhdW yheI yheJ dat yheN nhaC nhaX yheH yheG yheF 1,040,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His yfhP fabL 0.00 1,010,000bp RpoA-His yfhQ 5.00 yhdB lytF RpoC-His yfhO RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His yhxA yhzG RpoA-His csbB sspK RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 yfhE yfhD yfhF 920,000bp 960,000bp Experiment 1 recX yfhH yfhI 0.00 spo0M Experiment 2 yfhC ygaB sspE ygaC ygaD 5.00 ygzA ygaJ Experiment 1 yfhB yfiY 910,000bp Experiment 2 yfhA yfhK yfhM yfhJ yfhL 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 7 yheB yheE sspB yheD yheA yheC yhaX hemZ yhaZ yhaR yhaU khtT khtS natA natB yhaO yhaN yhaM yhzD hemH hemY yhgD yhgE yhfC yhgC yhgB yhfA yhfE fabHB 1,080,000bp yhfF gltT yhfI yhfJ yhfH 1,090,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yhfK lcfB yhfN yhfO yhfP yhfQ aprE yhxC phoE yhfS yhfT bioY hemAT yhfW comK yhzC yhjA yhxD yhjE sipV yhjG yhjB yhjH yhjC yhjD yhjM glcP ntdC ntdB ntdA 1,120,000bp yhjP yhjN yhjO addB addA sbcD sbcC yisB gerPE gerPC gerPF gerPD gerPB yhjQyhjR 1,130,000bp 1,140,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yisL wprA asnO yisN yisP yizA yisR yisQ degA yisS yisV yisT yisU yisY yisX yitC yitD yisZ yitA yitB yitQ yizB yitR nprB yitL yitE yitF yitG 1,170,000bp yitH yitI yitJ yitK 1,180,000bp yitM yitO yitP yitT yitS ipi yitV yitW yitY yitZ argC argJ argB argD carA yizC yitU 1,190,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His yhaA hemE 0.00 1,160,000bp RpoA-His hinT pbpF 5.00 gerPA yisJ gerPB yisI RpoC-His scoC yhaH trpP serC ecsC 0.00 yisK RpoA-His ecsA ecsB 1,070,000bp 1,110,000bp Experiment 1 yhaJ yhzF 5.00 yhfM Experiment 2 yhaI RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 yhfJ Experiment 1 yhzE prsA 1,060,000bp Experiment 2 yhaL 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 8 carA carB argF yjzC yjaU yjaV med yjzD comZ fabHA fabF yjaZ appD appF appA appA appB appC yjbA yjzB oppA RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 pepF yjbLyjbM ppnKA yjbO yizD yjbH yjbI yjbJ yjbK 1,230,000bp yjbQ tenA tenI thiO thiF thiD fabI prpE cotO cotZ 1,240,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 yjcZ yjcA yjzK spoVIF yjzE yjcD metI yjzF yjcO yjcN yjzG yjcP yjcQ yjcR yjcS yjdA metC yjcFyjcG yjcH 0.00 yjcK yjcL yjcM manR manP manA yjdF yjdB yjdI yjdG yjdH yjeA yjzH yjdJ 1,270,000bp ctaO cotT yjfC yjfA yjfB yjgC yjgD yjhA yjhB yjiB yjgA yjgB 1,280,000bp yjiA yjiC yjjA yjzI yjlB yjkA yjkB rex ndh yjlA 1,290,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 uxaC exuM yjmC yjmD uxuA uxuB exuT exuR uxaB uxaA yjoB yjoA rapA phrA xlyB yjpA xkdB xkdD xpf yjzJ xkdC ykzK xtrA yjqB yjqC yjqA xtmA xtmB xkdE xkdF xkdG xkdH xkdJ xkdK ykzM ykzL xkdI xkdN xkdO xkdM xkzB xkdP xkdQ xkdS xkdR xkdT xkdUxkzA xkdV xkdX xhlB xkdW xepA xhlA xlyA spoIISA spoIISB pit xkdA xre 1,320,000bp 1,330,000bp 1,340,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His mecA coiA 5.00 1,310,000bp RpoC-His yjbC spxA 0.00 yjnA RpoA-His yjbB 1,220,000bp RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 oppF yjbE 1,260,000bp Experiment 1 oppD 5.00 cotY cotX cotWcotV ndh oppC trpS 1,210,000bp Experiment 2 oppB thiG thiS 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 9 mhqA pit ykaA ykcB ykcC proG ykbA dppA dppB dppC dppD dppE ykfA ykfB ykfC ykgB guaD metE ispA ykoG ykoH thiX 1,380,000bp thiW ykoI ykoJ ykzD mgtE thiV thiU ykzO tnrA ykoN 1,390,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ykoS ykoT ykoQ ykoX ykoY ykoU ykoV sigI rsgI htpX ykzE ykzP ktrD ykrK sspD ykoW kinE ogt ykrP mtnE mtnA mtnK mtnW mtnX mtnB mtnD mtnU eag spo0E ykvA 1,420,000bp mhqR kinD ykvI motB motA queC queDqueE queF clpE 1,430,000bp ykvO ykvP ykvQ ykzQ ykzR ykvN ykvR ykzSykvT ykvU ykvS 1,440,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 stoA zosA ykvY ykvZ glcT ptsG ptsI ptsH splB splA mcpC ykwC pbpH kinA ykwD cheV patA ykzT fadH ykyB ykuC 1,470,000bp fadG ykzU ykuH ykuI ykuK ykuL ykuJ ykzF ccpC ykuN ykuO ykuP dapH dapL ykuD ykuE ykuS ykuT 1,480,000bp ykuUykuV rok mobA moeB moeA moaE mobB moaD yknU yknT 1,490,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His rsbRB 0.00 1,460,000bp RpoA-His ohrR ohrB ykzN 5.00 ykwB RpoC-His ohrA 0.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His ykvU RpoA-His proA ykzH 1,370,000bp 1,410,000bp Experiment 1 ykgA proB RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ykoN Experiment 2 ykjA ykoL ykzBykoM 5.00 ykoP Experiment 1 ykhA hmp htrA 1,360,000bp Experiment 2 ykfD ykkD ykkA ykkB ykkC purU 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 10 yknU yknV yknW yknX yknY yknZ fruR fruK fruA sipT ykpA panE ykoA abh kinC ampS rnjA pdhB pdhC pdhD defB ykzV ykzW slp yktA speA yktB ylaA yktD 1,530,000bp nprE ylaE bipA ylaH ylaK ylaJ ylaI ylaF 1,540,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 glsB ylaN ftsW pycA ctaB ctaC ctaD ctaE ctaFctaG ctaA ylbBylbC ylbE ylbD ylbF ylbG ylbH coaD ylbA ylbK ylbO ylbN rpmF ylbL ylbJ ylbM ylzH ylbQ mraZ mraW ftsL pbpB yllA spoVD murE mraY murD spoVE murG murB divIB ylxW ylxX sbp ftsA ftsZ bpr ylbP 1,570,000bp 1,580,000bp 1,590,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His pdhA 5.00 1,560,000bp RpoA-His ykzG ykyA 1,520,000bp RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ykrA 0.00 ylaL Experiment 1 adeC ylaC ylaB ylaD 5.00 ylaK Experiment 2 ktrC mreBH ykpC 1,510,000bp bpr ykqA suhB ykzI ykzC 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 spoIIGA sigE sigG ylmA thiQ ylmG ylmCylmD ylmE sepF ylmH divIVA ileS ylyA lspA rluD pyrR pyrP pyrB pyrC pyrAA pyrAB pyrK pyrD pyrF pyrE cysH cysP sat cysC sumT sirB sirC yloB yloC gmk coaBC ylzA rpoZ priA defA fmt rsmB yloN yloA 1,620,000bp 1,630,000bp 1,640,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 1,610,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 11 yloN prpC prkC cpgA rpe yloU thiN spoVM yloV sdaABsdaAA recG fapR plsX fabD rnc fabG acpA smc ftsY rpmB 1,670,000bp RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His ylqH sucC sucD dprA rnjB topA trmFO codV clpQ clpY codY fliG fliH fliI fliJ ylxF fliK flgD 1,680,000bp 1,690,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 fliL ylzI fliM fliY fliZ cheY fliP fliR fliQ flhB flhA flhF ylxH cheB cheA cheC cheW cheDsigD ylxL rpsB 1,710,000bp RpoA-His rnhB ylqG RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 flgD flgE Experiment 1 rplS rbgA flgC flgB fliE fliF ylqB 1,660,000bp Experiment 2 ylqC rimM rpsP ylqD trmD ffh ylxM tsf pyrH frr uppS cdsA dxr rseP proS polC ylxS nusA 1,720,000bp rplGA ylxR infB rbfA ylxP truB ribC rpsOpnpA 1,730,000bp ylxY mlpA spoVFA ymxH spoVFB asd dapG dapA rnjB 1,740,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 spoIIIE tepA ylzJ ymfC ymfD ymfF ymfH ymfI ymfK ymfM ymfJ ymfK pgsAcinA recA pbpX ymdA ymdB tdh spoVS kbl ymcB ymcA cotE mutS mutL pksA pksB pksC pksD pksE pksF acpK pksG pksH pksI pksJ ymzDymcC 1,770,000bp 1,780,000bp 1,790,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 1,760,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 12 pksL pksM 1,820,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ymzE ymzE ymaC ymaD ymaE ymzB aprX pksS ymzC nrdI ymaF miaA ymaH ymzA nrdE ebrA ebrB ymaG ynbB glnR glnA ynaD xynP xynB xylA xylB yncC xylR 1,880,000bp yncB yncE alrB 1,890,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ynzJ thyA yndA ynzByndD yndE yndF tatAC yncM ynzK cotC yndB yndG yndHyndJ yndKyndL yneB yneA ynzC tkt fosB yndM lexA yneF yneE ccdA yneI yneJ ynzD citB ynzL tlp yneP yneN sspN yneQ sspP yneK cotM sspO 1,920,000bp yneT parE yneR plsY 1,930,000bp parC alsT eglS ynfC ynfE xynC yngA yngB yngC xynD yngD yngE 1,940,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His ynbA 0.00 1,910,000bp RpoA-His spoVK 1,870,000bp RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ymaB ynaG ynaI ynaE ynaF ynzI 5.00 cotU Experiment 1 nrdF ynzF ynaB ynxB ynzG ynaC cwlC 1,860,000bp Experiment 2 1,840,000bp 0.00 pksR yncE yncF 1,830,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 1,810,000bp pksN 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 13 yngE yngF yngG yngHA yngHB yngI yngJ ynzE yngK yngL ppsE ppsD ppsC 1,970,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yoeA ggt yoeC yoeD yogA ftsR gltC gltB yoxC yoxB yoaA gltA proJ yoaC yoaD yoaG 2,020,000bp yoaH pelB exlX yoaM yoaK yoaQ yozS yoaN yozF yozT yoaR yoaO yoaP 2,030,000bp cyeA yoaU penP yoaW yoaZ yobA 2,040,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yobD pps xynA yozI yobE yozV yozH yozX yozY yobF yozW yozJ rapK yozZ phrK yozM yozL yobH yozK yobI yobN yoyA yobJ yobKyobL yobO yobW yobQ csaA yobR yobS yobT yobU yobV yobM 2,070,000bp 2,080,000bp czrA yocA yocC yocD des desK yozB yocB yocN yoyB yozN desR yocH yocI yocJ yocKyocL yocM yozO 2,090,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His yoaB yoaI 0.00 2,060,000bp RpoA-His yoxD yozQ 5.00 yozU yobA RpoC-His rtp yoaF 0.00 yobB RpoA-His proH yoaE yozG yoaS yoaT 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 1,990,000bp 5.00 2,010,000bp Experiment 2 yoxA 0.00 yoxA Experiment 1 1,980,000bp dacC 5.00 iseA Experiment 2 ppsA RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 1,960,000bp ppsB 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 14 dhaS sqhC sodF yozC yocS yocR norM odhB odhA yojO yojN sodC cwlS yojK deoD 2,130,000bp yodP yodQ yodR yodS yodT cgeE yoyG cgeD cgeC 2,140,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ypqP yotM yotN yotL sspC yotI yotF yotC yotJ yotG yotD yotH yotE yotB yotK yosU yosA yosV yosR yosXyosW yojWyosTyosS yosP yosQ nrdEB yosB yorY yorW yosL yosJyosH yosF yosD nrdIB yosKyosI yosGyosE yosC yorZ yorX yorV mtbP yoqW ligB yorS yorQ yorO yorM yorT yorR yorPyorN yorL yorK 2,170,000bp yorJ yorI yorH yorG yorF yorD yorB yorE yorC yorA 2,180,000bp yoqZ yoqY yoqX yoqT yoqO yoqM yoqE yoqR yoqJ yoqH yoqF yoqU yoqS yoqP yoqN yoqL yoqK yoqI yoqG yoqD 2,190,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yoyI yoyH yopQ yopP yopN yopL yopO yopM yopK yopG yopE yopI yopJ yopH yopF yopD yopC yonO yonP yopB yopA yonX yonV yonN yoyJ yonS yonU yonT yonR yonJ yonK yonHyonG yonF yonE yonD yonCyonB yomZ yomX yomV yomS yonA yomY yomW yomU youAyomTyomR yonI 2,220,000bp yomP yomN yomQ yomO yomM yomJ yomK yomI yozPyomL youB 2,230,000bp 2,240,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His yodJ yodM yodN yokU yodL yozD yozE kamA 5.00 2,210,000bp RpoA-His ctpA yoyF 0.00 yoqC yoqAyopY yopW yopU yoqD yoqB yopZ yopX yopV yopT yopR RpoC-His yodD yodE yoyE 5.00 yopS RpoA-His yodH yodI RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 Experiment 1 yodB 2,120,000bp 2,160,000bp Experiment 2 yojA yojB yodC 0.00 phy Experiment 1 yodA cgeB cgeA 5.00 cgeB Experiment 2 gerT yoyC yojG yojF yojE yojJ 2,110,000bp rsbRC yodF yoyD 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 15 yomI yomH yomG yomF yomE yomD blyA bhlB bhlA yolC bdbB yolJ bdbA sunT yokLyokK yokJ yokI yokH yokG yokA ypqP yokC yokB ypoP msrB msrA yplP ypmS ilvA ypmT ypmR scuA ypmP dinF 2,280,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yphP ilvD ypgR ugtP sspL ypdP ypdQ cspD ypzA ypeP degRypeQ ypgQ bsaA kduI exoA ypbS ypzF ypbR ypbQ bcsA pbuX xpt ypwA kdgT kdgA kdgK kdgR kduD ypzG ypvA 2,320,000bp yptA ypsC ypqA ypsA gpsB cotD yprB yprA ypqE 2,330,000bp yppF sspM recU ponA yppD yppG yppE yppC ypoC nth dnaD asnS aspB ypmA ypmB dinG 2,340,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 panC panD panB birA cca ypjH dapB ypjG mgsA ypjD ypzI ypjB ypjA qcrC qcrB qcrA ypiFypiB ypiA aroE tyrA hisC trpA trpB trpF trpC trpD trpE 2,370,000bp aroH aroB aroF cheR 2,380,000bp ndk hepT folEA menH hepS mtrB hbs spoIVA yphF yphE gpsA engA seaA ypzH yphA fni ypfD cmk ypfA ypfB ypeB sleB 2,390,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His ypiP 0.00 2,360,000bp RpoA-His ypjQypjP 5.00 dinG Experiment 1 ypkP dfrA thyB 2,290,000bp ypjC Experiment 2 yplQ RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His yolB yolA 2,270,000bp 2,310,000bp Experiment 1 yolD yokE yokD 0.00 metA Experiment 2 sunI sunA uvrX yokF 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 2,260,000bp ypiP yoyK yoyK 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 16 fer sleB prsW ypdA gudB mecB ypbG ypbFypbE ypbD recQ ypbB serA fmnP ypzE ypuF aroC rsiX sigX resE resD resC resB 2,420,000bp yqzK fur 2,440,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 mleN ansB ansA yqxK yqkF nudF yqkD yqkE yqzH yqjV yqkB yqkC yqkA yqjY polYB yqjZ yqjX yqjU proI yqjTcoaA dsdA yqjQ yqjP yqjM yqjL yqjN oxaAB yqzJ yqjF zwf rnz gndA 2,470,000bp polYA bmrU yqjE yqjD yqjC yqjB yqjA 2,480,000bp artR artQ artP bmr bmrR yqiW bkdB bkdAB bkdAA 2,490,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 buk bcd ptb bkdR prpB yqiG prpD prpC mmgC mmgB mmgA yqiK yqiI yqiH yqhQ spo0A spoIVB recN ahrC yqxC dxs ispA 2,520,000bp xseA xseB folD nusB yqhY accC 2,530,000bp spoIIIAG spoIIIAE spoIIIAC spoIIIAA efp accB spoIIIAH spoIIIAF spoIIIAD spoIIIAB yqhV yqhT yqhS yqhR yqhP yqhO yqhL mntR yqhM gcvPB yqhH gcvPA gcvT 2,540,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His ripX 0.00 2,510,000bp RpoA-His 2,430,000bp pupG drm 5.00 bkdAA lpdV RpoC-His spoVAF 0.00 yqzF RpoA-His lysA RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 ppiB spoVAEB spoVAB sigF spoIIAA spoVAEA spoVAD spoVAC spoVAA spoIIAB dacF 5.00 2,460,000bp Experiment 2 ypuDsipS ypuA 0.00 yqkK fur spoIIM mleA Experiment 1 ribE ribD ypuC ypuB ypzJ ypuC ypzD 5.00 ansR Experiment 2 ypuI spcB scpA ribH ypzK ribAB RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 2,410,000bp resA rluB spmA spmB dacB ypzC 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 17 yqhH yqhG sinR sinI yqzG tasA sipW yqxM yqhB comGG comGE comGC yqzE comGF comGD comGB comGA yqgY yqxL rsbRD yqzC yqzD yqgW mgsR yqgX yqgU yqgV yqgT yqgS yqgA 2,580,000bp yqfX zur yqfU nfo cshB yqfO trmK cccA 2,590,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 dnaG yqxD yqfL yqeW ccpN glyS glyQ era recO yqzL yqfG cdd dgkA yqfF phoH yqfD yqfB yqfC yqfA yqeZ yqeYrpsU rpsT rimO rsmE prmA dnaJ dnaK grpE hrcA 2,620,000bp hemN lepA yqxA spoIIP gpr yqzM holA comER comEC 2,630,000bp sda yqeL nadD aroD yqeM yqeK yqeI comEB comEA yqeH yqeG yqeD yqeF cwlH 2,640,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yqeB spoIVCB nucB spoIVCA rapE arsC arsB yqzI phrE yqcG yqcF yqdB yqxI yqxJ cwlA yqcKarsR yqcI yqxG yqxH yqcD yqcE yqcC yqcA yqcB yqbT yqbR yqbS yqbQ yqbN yqbN yqbP yqbO 2,670,000bp yqaP yqbM yqbK 2,680,000bp yqbJ yqbG yqbE yqzN yqbI yqbH yqbF yqbD yqbC yqbB yqbA yqaT yqaS yqaR yqaQ yqaE yqaN yqaM yqaO yqzO yqaL yqaK yqaJ yqaH yqaF yqaI yqaGyqdA yqaD 2,690,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His sodA yqgC 0.00 2,660,000bp RpoA-His yqgE 5.00 yqeC RpoC-His pbpA ispH 0.00 yqeD RpoA-His pstS yqfQ 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 pstC yqfT 0.00 2,610,000bp Experiment 2 pstBB pstBA pstA yqfW 5.00 sigA Experiment 1 yqgL 2,570,000bp antE Experiment 2 yqgN yqgM yqgO rpmGA yqfZ ispG RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 2,560,000bp glcK glpG yqgQ yqgB 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 18 yqaB spoIIIC yqaC yrkO yrkS psiE yrkQ yrkN yrkP blt yrkL yrkK yrkJ bltD yrzM yrkC bltR yrkF yrkE yrkD yrzN yrkB yrkI yrkH yrdQ yrkA 2,720,000bp alaS yraN csn 2,740,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yraF yraG adhB yraD yraE yraH adhA yrzP yraB yraA aapA sacC levG levF levE levD levR yrhO sigV rsiV yrhP oatA yrhK yrhE cypB bscR yrhH 2,770,000bp yrzI yrhG yrhD yrzA mccB yrhC yrhF mccA mtnN yrrT yrrS 2,780,000bp pbpI greA udk yrrO yrrN yrrM yrrL yrrK yrzB yrzL alaS 2,790,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 glnM glnP yrvN yrrD yrzR yrzQ yrrC yrrB trmU iscS cymR yrvJ yrvM aspS hisS yrzK spoVB dtd relA apt recJ yrvD yrvC secDF 2,820,000bp comN 2,830,000bp yrzE yrbG yrbF tgt yrzF queA ruvB yrzS ruvA bofC csbX yrbE yrzT yrzH yrbD nifS yrbC coxA safA nadA nadC nadB 2,840,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His yraO 5.00 2,810,000bp RpoA-His 2,730,000bp sigZ yraL 0.00 yrrI RpoC-His yrpE yraM 5.00 glnQ glnH RpoA-His yrdA aadK RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 yrdF cypA yrdD yrdD yrdD yrdC yrdB yrpG 0.00 2,760,000bp Experiment 2 yrdN azlC azlD azlB yrpD 5.00 yraJ yraI Experiment 1 czcD brnQ yrdK yrpC 0.00 yraK Experiment 2 yrdP yrpB 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 2,710,000bp yrdR yrzO gltR 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 19 nifS nadR yszA pheA yszB obg ysxB spoIVFB spo0B rpmA rplU spoIVFA minD minC mreD mreC mreB radC maf spoIIB comC folC valS spoVID hemL hemB hemD hemC abnA 2,880,000bp leuB leuA ilvC ilvH ilvB 2,890,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 gerM racE ysmA ysmB gerE sdhB sdhA sdhC lysC ysfB sspI rnhC uvrC trxA xsa etfA etfB fadB fadR lcfA yshE mutSB polX yshB yshA pheT pheS 2,920,000bp glcD glcF ysgA ysfE cstA abfA 2,930,000bp araQ araP araN araM araL araD araB araA abnA 2,940,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ysdC rplT infC ysdA rpmI yscB ysaA lrgB lrgA lytT lytS ytbD thrS ytxC ytxB dnaI dnaB nrdR speD gapB ytbE ytcD ytrI ytrH ytvI coaE ytaF mutM polA phoR 2,970,000bp phoP mdh icd 2,980,000bp citZ ytwI ytzA pyk pfkA accA accD ytsJ dnaE ytzJ nrnA ytpI ytoI ytnM ytnL 2,990,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His leuD leuC 0.00 2,960,000bp RpoC-His ysoA 5.00 ysdB RpoA-His tig RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 clpX 0.00 2,910,000bp Experiment 2 lonB 5.00 ysnBysnA rph Experiment 1 ysxC lonA 2,870,000bp yslB Experiment 2 hemX hemA RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 ysxD ysxE 2,860,000bp ysnE ysnD ysnF 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 20 ytlI ytnL rbfK ytnJ ytmO ytnI tcyN tcyM tcyL tcyK tcyJ ytmI ppnKB ytkL ytkK argH ytzD argG moaBackA ytxK tpx ytfJ ytfI ccpA aroA ytpS 3,040,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ytpR ytpQ ytpP ytzB ytoP ytzH malS ytnP trmB ytmP ytkP amyX ytlR ytlQ ytlP pbuO ytzE ytjP ythQ ythP ytfP opuD ytdP yteU yteV yteT ytzG ytgP 3,070,000bp yteSyteR msmR yteP ytcQ ytcP ytbQ 3,080,000bp bioI bioB bioD bioF bioK bioW msmE amyD ytaP 3,090,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ytvA ytvB yttA yttB ytqA bceB bceA bceS bceR ytrF ytrE ytrD ytrC ytrB ytrA ytzC ytqB ytoA ytpB ytpA pckA ytnA asnB 3,120,000bp metK ytlA ytmB ytmA 3,130,000bp ytlC ytlD ytzI ytkD ytkC dps ytkA luxS ytjA ythA ytiB rpmEB ythB ytzL mntD mntC mntB mntA menC menE menB ytxM 3,140,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His 3,030,000bp ytxE ytxD 5.00 3,110,000bp RpoA-His tyrS ytxH ytxJ ytxG murC 0.00 ytwF leuS RpoC-His ytrP acsA ytzK 5.00 amyD amyC melA RpoA-His yttP acuA acuB acuC RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 ezrA 3,020,000bp 3,060,000bp Experiment 2 iscS rpsD 0.00 ytpS Experiment 1 ytcI ytsP 5.00 ytoQ Experiment 2 ytcJ thiI sspA hisJ RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 3,010,000bp yteJ sppA braB 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 21 yteA ytxM menD menF ytcA ytcB ytcC ytdA cotI ytxO cotS ytaB cotSA thiT glgP glgA glgD glgC RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 3,180,000bp yubD uppP yubA yulE yulD yulC 3,190,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yugO mstX yulB yuxG tlpB mcpA tlpA mcpB yugU yuzH yugT yugS yugP yuzI yuzA yugM yugN pgi yugK yugJ yugF yugI yugH yugG patB kinB kapB yugE 3,220,000bp kapD yuxJ pbpD yuxK yufL yufM yufN yufO yufP yufQ maeN yufK mrpC mrpD mrpB mrpA yufS 3,230,000bp 3,240,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 mrpF mrpE mrpG yuzC comQ comX degQ yuxH yuzE pncB yueH yueF pncA yueI yueG yueE yuzF yueD yueC yueB yukF yukB yukC yukE yukD 3,270,000bp ald yukJ bioYB ybdZ dhbF 3,280,000bp dhbB dhbE dhbC dhbA besA yuiH yuiF yuiD pepA yuiA yuiC yuiB 3,290,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His yubF lytG yulF 0.00 3,260,000bp Experiment 1 gbsA cdoA 5.00 comA yuxO comP Experiment 2 yuaD gbsB ktrA ktrB 0.00 3,210,000bp mrpD yuaF yuaC yuaB 5.00 tgl yulC yuaI yuaG 3,170,000bp RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 3,160,000bp glgB yuaE 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 22 yumC yumB guaC yuzG yutJ paiB paiA yutM dapF yutK yuzB yutI yutG yuzD yuxL thrB thrC hom yutH yutC yutF yutE yutD yvqJ yunG pucH bsn pucE pucD pucC pucB pucA 3,330,000bp pucG pucF frlR yurJ frlD frlM frlN frlO 3,340,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yurS sspG frlB yurQ yurR yuzL yurTyuzN sufB iscU sufS sufD sufC yurZ yuzK metN metP metQ yusE yusG yusI yusD yusF yusH fadE fadA fadN yusN yuzM yusO yusP yusT yusR yusQ yusS fadM yusZ yusV yusU 3,370,000bp yusW yusY yusY mrgA cssR cssS htrB yuxN yuzO gerAA fumC 3,380,000bp yvzF gerAB gerAC liaR liaS liaF liaG liaH liaI yvqJ 3,390,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yvqK yvrA yvrB yvrC yvrJ oxdC yvrE yvrG yvrH sigO rsoA yvrL yvrN fhuD yvrO yvrP fhuC fhuG fhuB yvsG yvgJ lysP sspJ yvgL yvgM yvgK yvgO yvgN 3,420,000bp nhaK yvaA cysI 3,430,000bp cysJ helD bdbD yvgT bdbC copB copA csoR copZ yvaB yvaC yvaE yvaD yvaF yvaG 3,440,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His pucM yuzJ 0.00 3,410,000bp RpoC-His pucL 5.00 yvrD RpoA-His pucK RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 yunE yunF 3,320,000bp 3,360,000bp Experiment 1 yunB yunC yunD pucJ 0.00 frlO Experiment 2 lipA pucR 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 3,310,000bp lytH 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 23 rghRB rghRA yvaP yvaQ yvaM yvaG smpB rnr yvaK secG yvaV sdpAsdpB spbC opuCD sdpI sdpR opuCC opuCB opuCA opuBC opuBD opuBB opuBA yvzC yvbF rsbQ malK gapA cggR araE yvbT yvbU 3,480,000bp yvbW yvbX yvbY yvfW yvfV yvfU yvfT yvfS yvfR 3,490,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 rsbP yvfH ganA ganQ ganP cycB ganR yvfG yvfI sigL epsO slrR pnbA epsN epsM epsL epsK epsJ epsI epsH epsG epsF epsE epsD epsC epsB epsA 3,520,000bp sacB levB yvdR yvdT yvdS yveA yveG racX padC yveF pbpE cotR clpP yvdQ yvdP 3,530,000bp pgcM malL malK 3,540,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yvdJ mdxG mdxF mdxE mdxD mdxR yvdD yvdB yvcT yvdA yvzJ yvcS yvcR yvcQ yvcP yvpB yvcN crh whiA yvcK yvcJ yvcI trxB cwlO yvcD 3,570,000bp bmrA yvzA yvcB 3,580,000bp yvcA hisI hisF hisA hisH hisB hisD pelC hisG hisZ nagA yvoF ppaX yvoD lgt hprK nagBA yvoA yvnB 3,590,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His pgk 5.00 3,560,000bp RpoC-His tpiA rsbQ 0.00 yvdC RpoA-His pgm cyeB RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 eno 3,470,000bp 3,510,000bp Experiment 1 yvbJ araR 5.00 ganB Experiment 2 yvbG yvbK RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 3,460,000bp yvbH yvbI 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 24 yvnA yvnB cypX yvmB yvmA yvkN yvlC yvlD yvlB yvmC yvlA yvkC yvzB uvrA uvrB yvkB yvkA csbA minJ flgK 3,630,000bp yviA degU degS tagO tuaH 3,640,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 tuaG tuaF tuaE tuaD tuaC tuaB tuaA tuaA lytC lytB lytA gtaB yvzE ggaB yvzH mnaA ggaA yvzI tagA tagB tagH tagG tagF tagE 3,670,000bp tagC tagD gerBA lytD gerBB gerBC yvyI ywtF ywtE ywtG 3,680,000bp pgdS pgsA pgsE pgsB pgsC 3,690,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 rbsK rbsD rbsA rbsC rbsB ywsB ywsA ywrO alsD alsR alsS ywrK cotG ywrF ywrE ywrJ cotB cotH ywrC ywrB ywrA ywrD ywqM ywqN ywqO ywqB ywqL ywqK ywqJ 3,720,000bp ywqH ywqI ywqG ywqF 3,730,000bp ywqE ptkA ywqC ywzD ywqA ywpF ywpJ glcR ssbB ywpG ywpE ywpD rapD mscL fabZ ywoH flhP flhO mbl ywoG usd spoIIID 3,740,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His yvyC hag 0.00 3,710,000bp RpoA-His secA RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His pgsB RpoC-His prfB comFB flgM yvyG yvyF comFC comFA 5.00 rbsR RpoA-His cccByvjA fliW csrA yviE flgL 0.00 3,660,000bp Experiment 1 ftsE fliT yvyD yvzG fliS fliD 5.00 tuaH Experiment 2 ftsX 3,620,000bp lytR Experiment 1 swrAA swrAA ctpB RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 3,610,000bp Experiment 2 yvyE yvhJ 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 25 ywoG amtB ywoF pucI ywoD glnK bcrC ywoC ywoB ywnH ywnG ywnJ spoIIQ clsA ywnC ywnF mta ywmA ureA ywzF ywmF ureB ywzE csbD rapB ywnB ywnA ureC ywkB atpA upp glyA 3,780,000bp ywlG ywlF ywlEywlD ywlC ywlBspoIIR ywkB 3,790,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 maeA tdk rho rpmEA ywjI murAB ywjH fbaA spo0F clsB pyrG rpoE acdA ywjD fadF ywjC sboX sboA albA ywiC ywjB ywjA ywiE narI narJ narH narG arfM 3,820,000bp fnr narK argS albC albB albD albE albF albG ywiB rapF ywhL 3,830,000bp ywhK ywhH phrF speB pbpG speE 3,840,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 ywhB rsfA mmr ywgB ywgA ywfO ywzC ywfI ywfM ywfL cysL pta ywfH ywdL bacF bacE bacD bacC bacB bacA ywfA rocC 3,870,000bp rocB rocA rocG 3,880,000bp yweA spsL spsK spsJ spsI spsG spsF spsE spsD spsC spsB spsA ywdK ywdJ ywdH ywdI ung ywdF ywdE ywdD 3,890,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His atpG 0.00 3,860,000bp RpoA-His atpC atpD 5.00 ywhDywhC ywhA thrZ RpoC-His ywmB ywzB 0.00 pbpG RpoA-His murAA prmC ywkF prfA RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 Experiment 2 spoIID ywkDracA 5.00 3,810,000bp Experiment 1 ywmC 3,770,000bp ywjG Experiment 2 fdhD atpB atpH atpF atpE atpI RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 3,760,000bp moaA ywmD ywmE ywlA 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 26 pdxK ywdDywzG ywcJ sacA ywdA sacP vpr sacT ywcE ywcI ywcH nfrA ywzA qoxC qoxD qoxB rodA qoxA galT ywbD ywbB ywbA 3,930,000bp ywaE tyrZ gspA ywaD ywaF ywaC 3,940,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 dltA ywzH dltD dltC dltB dltE ilvK katX licH licC licA yxlH aag yxzF licB licR yxlA yxlG yxlF yxlD sigY yxlE yxlC cimH yxkO cydD cydC 3,970,000bp cydB yxkI yxzE cydA yxkH aldY msmX yxkF yxkC yxkD 3,980,000bp yxjO galE yxjN yxjM yxjL pepT yxjJ yxjI yxjH yxjG yxkA 3,990,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yxjA scoB scoA yxjC yxjB citH yxiT yxiT yxiS katE yxiO bglS licT yxiP hutP hutH deaD yxiM yxzJ yxiJ yxiH yxzC yxzI yxiK yxiI yxzG yxiG yxiF yxxG wapA yxxF 4,020,000bp 4,030,000bp yxiE bglH bglP yxxD yxxE yxiD yxiB yxiC abnB yxzL hutU hutI hutG hutM pdp 4,040,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His ywbI sacY 5.00 4,010,000bp RpoA-His thiE thiM sacX 0.00 yxjF RpoC-His efeU epr 5.00 yxjG RpoA-His efeM ywbC RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 ywbO efeN 3,920,000bp 3,960,000bp Experiment 2 ywcD ywcC ywbE 0.00 ywaC menA Experiment 1 galK cidA lrgB ywbF 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 3,910,000bp Experiment 2 ywcA slrA ywcB 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 27 yxeE yxeD pdp nupC deoC deoR yxxB yxeR yxeQ yxeP yxeO yxeN yxeM yxeLyxeK yxeI yxeJ yxeH yxeG yxeF yxeB yxeC iolR yxeA yxdM iolE iolD iolC iolB mmsA htpG 4,080,000bp yxcA yxbF yxbD yxbC 4,090,000bp 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yxaM yxaI yxaJ yxnA yxaH qodI yxaF yxzK yxaC yxaD gntR gntK yxaB gntP gntZ ahpC ahpF glxK yydK yyzN bglA yyzE yydJ yydI fbp yydH yydG yycS yydF yydD 4,120,000bp yydC yydB rapG yydA yyzF yycR yycQ yyzG yycP 4,130,000bp yycO yycN phrG argI rocR rocE rocD yyzO htrC yycJ yycI 4,140,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 yycB yycDyycC walK walR purA yycE dnaC yyzB yycA cotF rplI yybT yybS ppaC yyzH yybR yybO yybP yybNyybM yybL yybK yybJ yyzJ yyzL yyzI yyzK yybG yybI 4,170,000bp yybH yybE yybF 4,180,000bp yybDyybC yyaTyyaS yybB yybA yyaR yyaN yyaO yyaM yyaQ yyaP tetB tetL yyaL yyaJ yyaK yyaH maa ccpB ssbA exoAA rpsR rpsF engD 4,190,000bp 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His iolF 5.00 4,160,000bp RpoC-His iolG 0.00 yycI walH RpoA-His iolH 5.00 RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 1 iolI 4,070,000bp 4,110,000bp Experiment 2 iolJ aldX 0.00 yxaL Experiment 1 yxdJ yxbG 5.00 asnH Experiment 2 yxdK yxcE yxcD csbC RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoAdel RpoAint RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 4,060,000bp yxdL iolS yxnB yxbB aslA asnH 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 28 yyaC engD yyaE yyaD yyzM yyaB parB parA noc rsmG trmF trmE jag rpmH oxaAA rnpA del int del int del int del int RpoA RpoA RpoA RpoA RpoA RpoA RpoA RpoA RpoC-His RpoA-His RpoC-His RpoA-His Experiment 2 Experiment 1 4,210,000bp 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 5.00 0.00 29 S10. Fig. Genome-wide RNAP binding profiles determined by ChAP-chip analysis. RpoAint-His, RpoAdel-His and RpoC-His were used as bait for the purification of RNAP complexes. The gene arrangement on the B. subtilis chromosome is shown by thick arrows at the top of the figure. Colors: sky blue indicates genes that are downregulated in rpoAdel-expressing cells compared with rpoAint-expressing cells, as determined by transcriptomic analysis; green indicates the top 50 genes showing the greatest reductions in RNAP binding among rpoAdelexpressing cells versus rpoAint-expressing cells; and dark blue indicates the genes that showed both transcriptomic down-regulation and high-level reductions in RNAP binding in rpoAdel-expressing cells.
