SAPK/JNK Signaling Cascades
Anuncio
www.cellsignal.com SAPK/JNK Signaling Cascades FasL, UV Inflammatory Cytokines Cellular Stress, γ Radiation Oxidative Stress Growth Factors, UV Daxx Rho cdc42 Rac RIP Ras TRAF2 Sos TRADD GRB2 Shc CrkL Crk RTKs G12/13-coupled Receptors Rac cdc42 Gα 12/13 PI3K Gβγ PI3Kγ GCKs MEKK1, MLKs HPK ASK1 MEKK1/4 MLKs MEKK1, MLK3 MEKK1, MLKs POSH MKK4/7 Apoptosis JIP1,2,3 JNK1/2/3 TAK1 IRS-1 MKP’s M3/6 NO JNK s JNK leu Nuc c-Jun ATF-2 Elk-1 SMAD4 p53 NFAT4 NFATc1 Transcription KEY Stat3 HSF1 Growth Differentiation Survival Apoptosis Kinase Direct Stimulatory Modification Transcriptional Stimulation Phosphatase Direct Inhibitory Modification Transcriptional Inhibition Transcription Factor Multistep Stimulatory Modification Translocation Multistep Inhibitory Modification Separation of Subunits or Cleavage Products Tentative Stimulatory Modification Tentative Inhibitory Modification © 2002 - 2007 Cell Signaling Technology, Inc. Joining of Subunits SAPK_JNK.eps • created January 2002 • revised November 2006