Our results show that CCRT followed by surgery gets excellent

LONG TERM RESULTS: CHEMORADIOTHERAPY (CCRT) PLUS
SURGERY IN PATIENTS WITH LOCALLY ADVANCED CERVICAL
CARCINOMA
J.T. ANCHUELO LATORRE1, A. KANNEMANN1, A.S. GARCÍA BLANCO1, M. FERRI MOLINA1, P. GALDÓS BARROSO1, A. MUÑIZ GARCIA1, J.C. MENENDEZ GARCIA1, J. CARDENAL
CARRO1, R. FABREGAT BORRAS2, H. VIDAL TRUEBA3, R. JIMENO MATE4, S. HERMANA RAMIREZ5, J. ESTEVEZ TESOURO6, P. PRADA GOMEZ1.
1HOSPITAL
UNIVERSITARIO MARQUÉS DE VALDECILLA, RADIATION ONCOLOGY, SANTANDER, Spain.
2HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA, PHYSICS, SANTADER, Spain.
3HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA, RADIOLOGY, SANTANDER, Spain.
4HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA, MEDICAL ONCOLOGY, Santander, Spain.
5HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA, PATOLOGY, SANTANDER, Spain.
6HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA, GYNECOLOGY, SANTANDER, Spain.
OBJECTIVES
To evaluate pathological
response and clinical
outcomes in women with
locally advanced cervical
cancer treated with
chemoradiotherapy and
surgery in a tertiary hospital.
METHODS
•
•
•
•
•
•
•
•
•
•
•
Retrospective analysis.
59 patients with cervical cancer (FIGO stages IA-IVB)
December 2004 and July 2015 with CCRT followed by surgery.
EXTERNAL BEAM RADIOTHERAPHY (EBRT) at 46-50,4 Gy, 1,8-2
Gy/day.
If aortic nodes were demonstrated, extended EBRT was
administered.
Boost to affected nodes or parametria (60 - 68 Gy, 2 Gy/day).
After 4 weeks of treatment, brachytherapy from 15 to 26 Gy in 3-6
fractions with 2D planification or 3D planification (n=28) was
administered.
Total tumour dose (D2): 85 - 90 Gy.
Concurrent chemo with weekly platin and in some cases oral 5-FU.
Overall treatment time ≤ 8 weeks.
All patients completed surgery between 4-15 weeks after CCRT.
RESULTS
•
•
•
•
Median age: 52y (30 - 77).
Squamous cell carcinoma: 81%.
All patients received hysterectomy.
7 patients (12%) underwent lymphadenectomy.
• RESPONSE:
• Complete response: 32 patients (54%).
• Residual microscopic disease: 7 (12%).
• Partial response: 20 (34%).
• Median follow up: 53 months (2 - 128 m).
• OS was 85% and DFS 81%.
CONCLUSIONS
ESTRO 2016
Our results show that CCRT followed by surgery gets excellent outcomes with
acceptable toxicity and may reduce local recurrences. Besides, it enables
assessment of the pathological response.
1311-EP
Clinical track: Gynaecological (endometrium, cervix, vagina, vulva)
Javier Tomás Anchuelo Latorre
DOI: 10.3252/pso.eu.ESTRO2016.2016
Poster
presented at: