Dietary Advanced Glycation End Products and Their Role in Health

Dietary Advanced Glycation End Products and Their Role
in Health and Disease
Por:Uribarri, J (Uribarri, Jaime)[ 1 ] ; del Castillo, MD (Dolores del Castillo, Mara)[ 2 ] ; de la Maza,
MP(Pia de la Maza, Mara)[ 3 ] ; Filip, R (Filip, Rosana)[ 4 ] ; Gugliucci, A (Gugliucci,
Alejandro)[ 5 ] ;Luevano-Contreras, C (Luevano-Contreras, Claudia)[ 6 ] ; Macias-Cervantes,
MH (Macias-Cervantes, Maciste H.)[ 6 ] ; Bastos, DHM (Markowicz Bastos, Deborah
H.)[ 7 ] ; Medrano, A (Medrano, Alejandra)[ 8 ] ; Menini, T (Menini, Teresita)[ 5 ] ...Más
ADVANCES IN NUTRITION
Volumen: 6
Número: 4
Páginas: 461-473
DOI: 10.3945/an.115.008433
Fecha de publicación: JUL 2015
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Resumen
Over the past 2 decades there has been increasing evidence supporting an important
contribution from food-derived advanced glycation end products (AGEs) to the body pool of
AGEs and therefore increased oxidative stress and inflammation, processes that play a major
role in the causation of chronic diseases. A 3-d symposium (1st Latin American Symposium of
AGEs) to discuss this subject took place in Guanajuato, Mexico, on 1-3 October 2014 with the
participation of researchers from several countries. This review is a summary of the different
presentations and subjects discussed, and it is divided into 4 sections. The first section deals
with current general knowledge about AGEs. The second section dwells on mechanisms of
action of AGEs, with special emphasis on the receptor for advanced glycation end products and
the potential role of AGEs in neurodegenerative diseases. The third section discusses different
approaches to decrease the AGE burden. The last section discusses current methodologic
problems with measurement of AGEs in different samples. The subject under discussion is
complex and extensive and cannot be completely covered in a short review. Therefore, some
areas of interest have been left out because of space. However, we hope this review illustrates
currently known facts about dietary AGEs as well as pointing out areas that require further
research.
Palabras clave
Palabras clave de autor:nutrition; oxidative stress; inflammation; insulin
resistance; RAGE;nutraceutical
Información del autor
Dirección para petición de copias: Uribarri, J (autor para petición de copias)
Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
Direcciones:
[ 1 ] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA
[ 2 ] Spanish Natl Res Council, Food Sci Res Inst, Dept Food Anal & Bioact, Food Biosci
Grp, Madrid, Spain
[ 3 ] Univ Chile, Inst Nutr & Food Technol Dr Fernando Monckeberg B, Santiago, Chile
[ 4 ] Univ Buenos Aires, Sch Pharm & Biochem, Inst Drug Chem & Metab, Dept
Pharmacognosy, Buenos Aires, DF, Argentina
[ 5 ] Touro Univ Calif, Coll Osteopath Med, Vallejo, CA USA
[ 6 ] Univ Guanajuato, Dept Med Sci, Guanajuato, Mexico
[ 7 ] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, Brazil
[ 8 ] Univ Republica, Sch Chem, Dept Food Sci & Technol, Montevideo, Uruguay
[ 9 ] Univ Lleida, Biomed Res Inst Lleida, Sch Med, Metab Pathophysiol Dept, Lleida, Spain
[ 10 ] Catholic Univ Maule, Fac Med, Biomed Res Lab, Talca, Chile
[ 11 ] Univ Guanajuato, Dept Chem, Guanajuato, Mexico
Direcciones de correo electrónico:[email protected]
Editorial
AMER SOC NUTRITION-ASN, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
Categorías / Clasificación
Áreas de investigación:Nutrition & Dietetics
Categorías de Web of Science:Nutrition & Dietetics
Información del documento
Tipo de documento:Review
Idioma:English
Número de acceso: WOS:000358224000009
ID de PubMed: 26178030
ISSN: 2161-8313
eISSN: 2156-5376
Información de la revista
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Impact Factor: Journal Citation Reports®
Otra información
Número IDS: CN2AZ
Referencias citadas en la Colección principal de Web of Science: 91
Veces citado en la Colección principal de Web of Science: 0