PERSONAL/STAFF Apellidos, Nombre/ Surname, First name

PERSONAL/STAFF
Apellidos, Nombre/
Categoría/
Surname, First name
Position
Navas Antón, José María
Investigador A1
E-mail
Teléfono/
Telephone
[email protected]
91 3474155
Fernández Cruz, María Luisa Científico Titular de OPIs
[email protected]
91 3478788
Alté García-Olías, Luis
Ayudante de I+D+i de OPIs
[email protected]
91 3478712
Bermejo, Azucena
Titulado Superior
[email protected]
91 3473907
Galbis, Liliana
Titulado Superior
[email protected]
91 3478712
Hernández, David
Titulado Superior
[email protected]
91 3476889
Kalman, Judit
Titulado Superior
[email protected]
91 3473907
Magaña, Cristina
Titulado Superior
[email protected]
91 3474167
Paz, Marina
Titulado Superior
[email protected]
91 3474167
Portolés, Marta
Titulado Superior
[email protected]
91 3474167
Santos, Alicia
Titulado Superior
[email protected]
91 3474167
Habila, Safia
Estudiante pre-doctoral
[email protected]
91 3478754
García, Victor
Estudiante pre-doctoral
[email protected]
91 3473907
Hernández, Javier
Titulado Medio
[email protected]
91 3478712
Garnica, Alicia
Empleabilidad Juvenil
[email protected]
91 3478754
Escario, Miguel
Empleabilidad Juvenil
[email protected] 91 3474167
Serrano, Verónica
Empleabilidad Juvenil
[email protected]
91 3474167
PROYECTOS COMPETITIVOS / COMPETITIVE PROJECTS
National Project RTA2009-00074-00-00. “Endocrine disruption related to farm residues”. INIA. 2009–
2013. Coordinator: José María Navas. Budget: 120.531€
Iberoamérica Project Acción 109Ac0371 “Scientific cooperation for the search of strategies of control
and prevention of mycotoxins in agricultural production”. CYTED IBEROAMERICA. 9 participants. July
2011 – December 2012. Coordinator: Ana María Catalina Dalcero (Córdoba, Argentina); Main
researcher at the INIA: María Luisa Fernández-Cruz
FP7 People. Marie-Curie. Initial Training Network (ITN). “ECO. Environmental ChemOinformatics”. October
2009 – September 2013. Coordinator: Igor Tetko (Helmholtz Centre for Environmental Health, Munich,
Germany). Main Researcher at INIA: José María Navas. Budget 3.386.676 € total (388.922 € for INIA)
FP7 Project MARINA. Managing Risks of Nanomaterials. European Commission. 46 participants. October
2011-October 2015. Coordinator Lang Tran (IOM, Institute of Occupational Medicine, UK) Main
Researcher in the INIA: José María Navas. Budget: 9.000.000 € total (120.000 € for INIA).
National Project RTA2012-00053-00-00. “Endocrine disruption and toxic effects related to the presence
of hormones, antibiotics, mycotoxins and other substances in farm residues”. INIA. June 2013 - June
2016. Coordinator: José María Navas. Budget: 120.000 €
FP7 Project SUN. “Sustainable Nanotechnologies” (Grant agreement nº 604305). European
Commission. October 2013-April 2017. Coordinator: Antonio Marcomini (Universita Ca’Foscari,
Venezia). Main researcher at INIA: José María Navas. Total budget: 10.249.962,00 €; INIA: 189 004 €.
FP7 Project GUIDEnano. “Assessment and mitigation of nano-enabled product risks on human and
environmental health: Development of new strategies and creation of a digital guidance tool for
nanotech industries” (Grant agreement nº 604387). European Commission. 26 participants. November
2013-May 2017. Coordinator: Socorro Vázquez (LEITAT, Barcelona, Spain). Main researcher at the INIA:
María Luisa Fernández Cruz. Total budget: 8.160.000 €; INIA: 342.796 €.
H2020 Project NanoReg2. “Development and implementation Grouping and Safe-by-Design
approaches within regulatory frameworks” (Grant agreement nº 646221). European Commission. 37
participant entities. September 2015 – August 2018. Coordinator: Emeric Frejafon (INERIS, Paris,
France). Main researcher at INIA: José María Navas. Budget 10.000.000 €; INIA: 112.500€
CONVENIOS O ENCOMIENDAS CON LA ADMINISTRACIÓN / TECHNICO-SCIENTIFIC PROJECTS WITH
THE ADMINISTRATION
Agreement AEG09-036 between INIA and the Ministry of Environment for the national implementation
and application of the Stockholm Convention and the regulation 850/2004/CE about Persistent Organic
Pollutants (POPs). 2009-2011. Coordinator: José María Navas. Total budget: 1.100.000 €
Agreement AEG07-060 between INIA and the Ministry of Environment to aply the REACH Regulation
and related rules including those of Biocides and Plant Protection Products. 2009-2011. Coordinator:
José María Navas. Total budget: 1.519.500 €.
Agreement EG13-074 between INIA and the General Direction of Environment Quality and Evaluation
for the environmental risk assessment of substances and chemical products according to the National
and European regulations. (November 2013 – December 2016). Coordinators: José María Navas and
María Luisa Fernández Cruz. Total budget: 603.500,00 €
ARTÍCULOS EN REVISTAS DEL SCI / SCIENTIFIC ARTICLES IN SCI JOURNALS
Fernández-Cruz, M.L., Valdehita, A., Alonso, M., Mann, E., Herradón, B., Navas, JM. 2011. Biological and
chemical studies on the aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its
condensation product pifithrin-β. Life Sciences 88: 774-783
De la Casa-Resino I, Valdehita A, Soler F, Navas JM, Pérez-López M. 2012. Estrogenic effects caused by oral
administration of atrazine in European quail (Coturnix coturnix coturnix). Comparative Biochemistry and
Physiology, Part C 156: 159-165.
Hernando MD, Rosenkranz P, Ulaszewska MM, Fernández-Cruz ML, Fernández-Alba AR, Navas JM. 2012.
Dose-response effects in vitro of poly(amidoamine) dendrimers (amino-terminated and surface modified
with [N-(2-hydroxydodecyl)] groups) and quantitative determination by a liquid chromatography- hybrid
quadrupole/time of flight mass spectrometry based method. Analytical and Bioanalytical Chemistry 404:
2749-2763
Mezcua M, Martínez-Uroz MA, Gómez-Ramos MM, Gómez MJ, Navas JM, Fernández-Alba AR. 2012.
Analysis of synthetic endocrine-disrupting chemicals in food: A review. Talanta 100: 90-106.
Quesada-García A, Valdehita A, Fernández-Cruz ML, Leal E, Sánchez E, Martín-Belinchón M, Cerdá-Reverter
JM, Navas JM. 2012. Assessment of estrogenic and thyrogenic activities in fish feeds. Aquaculture 338-341:
172-180
Rosenkranz P, Fernández-Cruz ML, Conde E, Ramírez-Fernández MB, Flores JC, Fernández M, Navas JM.
2012. Effects of cerium oxide nanoparticles to fish and mammalian cell lines: an assessment of cytotoxicity
and methodology. Toxicology In Vitro 26: 888-896.
Valdehita A, Fernández-Cruz ML, Torrent F, Navas JM. 2012. Differences in the induction of CYP1A and
related genes in cultured rainbow trout Oncorhynchus mykiss. Additional considerations for the use of
EROD activity as biomarker. Journal of Fish Biology 81: 270-287.
Campos B, Rivetti C, Rosenkranz P, Navas JM, Barata C. 2013. Effects of nanoparticles of TiO2 on food
depletion and life-history responses of Daphnia magna. Aquatic Toxicology 130-131: 174-183.
Connolly M, Pérez Y, Mann E, Herradón B, Fernández-Cruz ML, Navas JM. 2013. Peptide-biphenyl hybridcapped AuNPs: stability and biocompatibility under cell culture conditions. Nanoscale Research Letters 8:
315.
De la Casa-Resino I, Hernández-Moreno D, Navas JM, Soler F, Pérez-López M. 2013. Non-destructive
multibiomarker approach in European quail (Coturnix coturnix coturnix) exposed to the herbicide atrazine.
Archives of Environmental Contamination and Toxicology 65: 567-574.
Cockburn A, Brambilla G, Fernández ML, Arcella D, Bordajandi LR, Cottrill B, van Peteghem C, Dorne JL.
2013. Nitrite in feed: From animal health to human health. Toxicology and Applied Pharmacology 270:
209-217.
Dorne JL, Fernández-Cruz ML, Bertelsen U, Renshaw DW, Peltonen K, Anadon A, Feil A, Sanders P, Wester
P, Fink-Gremmels J. 2013. Risk assessment of coccidiostatics during feed cross-contamination: Animal and
human health aspects. Toxicology and Applied Pharmacology 270: 196-208.
Fernández-Cruz ML, Lammel T, Connolly M, Conde E, Barrado A, Sylvain D, Pérez Y, Fernández M, Furger
C, Navas JM. 2013. Comparative cytotoxicity induced by bulk and nanoparticulated ZnO in the fish and
human hepatoma cell lines PLHC-1 and Hep G2. Nanotoxicology 7: 935 – 952
Lammel T, Boisseaux P, Fernández-Cruz ML, Navas JM. 2013. Internalization and cytotoxicity of graphene
oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line HepG2.
Particle and Fiber Toxicology 10:27.
Malhão F, Urbatzka R, Navas JM, Cruzeiro C, Monteiro RAF, Rocha E. 2013. Cytological,
immunocytochemical, ultrastructural and growth characterization of the rainbow trout liver cell line RTLW1. Tissue and Cell 45: 159-174.
Quesada-García A, Valdehita A, Torrent F, Villarroel M, Hernando D, Navas JM. 2013. Use of fish farms to
assess river contamination: combining biomarker responses, active biomonitoring, and chemical analysis.
Aquatic Toxicology 140 – 141: 439-448.
Scholz S, Sela E, Blaha L, Braunbeck T, Galay-Burgos M, García-Franco M, Guinea J, Klüver N, Schirmer K,
Tanneberger K, Tobor-Kapłon M, Witters H, Belanger S, Benfenati E, Creton S, Cronin MTD, Eggen RIL,
Embry M, Ekman D, Gourmelon A, Halder M, Hardy B, Hartung T, Hubesch B, Jungmann D, Lampi MA, Lee
L, Léonard M, Küster E, Lillicrap A, Luckenbach T, Murk AJ, Navas JM, Peijnenburg W, Repetto G, Salinas
E, Schüürmann G, Spielmann H, Tollefsen KE, Walter-Rohde S, Whale G, Wheeler JR, Winter MJ. 2013. A
European perspective on alternatives to animal testing for environmental hazard identification and risk
assessment. Regulatory Toxicology and Pharmacology 67: 506 – 530.
Valdehita A, Quesada-García A, Delgado MM, Martín JV, García-González MC, Fernández-Cruz ML, Navas
JM. 2013. In vitro assessment of thyroidal and estrogenic activities in poultry and broiler manure. Science
of the Total Environment 472: 630-641.
De la Casa-Resino I, Navas JM, Fernández-Cruz ML. 2014. Chlorotriazines do not activate the aryl
hydrocarbon receptor, the estrogen receptor and thyroid receptor in in vitro assays. ATLA 42: 25 - 30.
Faria M, Navas JM, Soares AMVM, Barata C. 2014. Oxidative stress effects of titanium dioxide
nanoparticles in zebrafish embryos. Science of the Total Environment 470-471: 379-389.
Lammel T, Navas JM. 2014. Graphene nanoplatelets spontaneously translocate into the cytosol and
physically interact with cellular organelles in the fish cell line PLHC-1. Aquatic Toxicology 150: 55-65.
Oliveira E, Casado M, Faria M, Soares A, Navas JM, Barata C, Piña B. 2014. Transcriptomic response of
zebrafish embryos to polyamidoamine (PAMAM) dendrimers. Nanotoxicology 8: 92-99.
Quesada-García A, Valdehita A, Kropf C, Casanova-Nakayama A, Segner H, Navas JM. 2014. Thyroid
signalling in imune organs and cells of the teleost fish rainbow trout (Oncorhynchus mykiss). Fish &
Shellfish Immunology. 38:166-174
Song L, Connolly M, Fernández-Cruz ML, Vijver MG, Fernández M, Conde E, de Snoo GR, Peijnenburg
WJGM, Navas JM. 2014. Species specific toxicity of copper nanoparticles among mammalian and piscine
cell lines. Nanotoxicology 8: 383-393.
Tetko IV, Schramm K-W, Knepper T, Peijnenburg WJGM, Hendriks AJ, Navas JM, Nicholls IA, Öberg T,
Todeschini R, Schlosser E, Brandmaier S. 2014. Experimental and theoretical studies in the EU FP7 Mrie
Curie initial training network project, Environmental ChemOinformatics (ECO). ATLA 42: 7-11.
Cano-Sancho González-Arias CA, Ramos AJ, Sanchis V, Fernández-Cruz ML. 2015. Cytotoxicity of the
mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol. Toxicology in
Vitro 29: 1639-1646.
Connolly M, Fernández-Cruz ML, Navas JM. 2015. Recovery of redox homeostasis altered by CuNPs in H4IIE
liver cells does not reduce the cytotoxic effects of these NPs: An investigation using arylhydrocarbon
receptor (AhR) dependent antioxidant activity. Chemico Biological Interactions 228: 57 – 68.
Connolly M, Fernández-Cruz ML, Quesada-García A, García-Olias LA, Segner H, Navas JM. 2015.
Comparative cytotoxicity study of silver nanoparticles (AgNPs) in a variety of rainbow trout cell lines (RTLW1, RTH-149, RTG-2) and primary hepatocytes. International Journal of Environmental Research and Public
Health 12: 5386-5405.
Lammel T, Boisseaux P, Navas JM. 2015. Potentiating effect of graphene nanomaterials on aromatic
environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell
line PLHC-1. Environmental Toxicology 30: 1192 – 1204.
Lingxiangyu L, Fernández-Cruz ML, Connolly M, Conde E, Fernández M, Schuster M, Navas JM. 2015. The
potentiation effect makes the difference: Non-toxic concentrations of ZnO nanoparticles enhance Cu
nanoparticle toxicity in vitro. Science of the Total Environment 505: 253-260.
Lingxiangyu L, Fernández-Cruz ML, Connolly M, Schuster M, Navas JM.2015. Dissolution and aggregation
of Cu nanoparticles in culture media: Effects of incubation temperature and particle size. Journal of
Nanoparticle Research 17:38.
Mary VS, Valdehita A, Navas JM, Rubinstein HR, Fernández-Cruz ML. 2015. Effects of aflatoxin B1,
fumonisin B1 and their mixture on the aryl hydrocarbon receptor and the cytochrome P450 1A induction.
Food and Chemical Toxicology 75: 104-111.
Quesada-García A, Valdehita A, del Olmo I, Gómez MJ, Navas JM. 2015. Identification of effects caused by
very low levels of chemicals present in riverine sediments by combining chemical analysis, in vitro
bioassays and the use of farmed fish as sentinels. Archives of Environmental Contamination and Toxicology
68: 663-677.
Connolly M, Fernández M, Conde E, Torrent F, Navas JM, Fernández-Cruz ML. 2016.Tissue distribution of
zinc and subtle oxidative stress effects after dietary administration of ZnO nanoparticles to rainbow trout.
Science of the Total Environment 551-552:334-343.
Quesada-García A, Encinas P, Valdehita P, Baumann L, Segner H, Coll J, Navas JM. 2016.Thyroid active
agents T3 and PTU differentially affect immune gene transcripts in the head kidney of rainbow trout
(Oncorhynchus mykiss). Aquatic Toxicology 174:159-168.
Hernández-Moreno D, Lingxiangyu L, Connolly M, Conde E, Fernández M, Schuster M, Navas JM,
Fernández-Cruz ML. 2016. Mechanisms underlying the enhancement of toxicity caused by the
coincubation of zinc oxide and copper nanoparticles in a fish hepatoma cell line. Environmental Toxicology
and Chemistry, in press.
Valdehita A, Fernandez-Cruz ML, Gonzalez-Gullon M, Becerra-Neira E, Delgado MM, Garcia-Gonzalez MC,
Navas JM. 2016. Androgens and androgenic activity in broiler manure assessed by means of chemical
analyses and in vitro bioassays. Environmental Toxicology and Chemistry, in press.
TESIS DOCTORALES / DOCTORAL THESIS
Title: Mechanisms of activation of the aryl hydrocarbon receptor in fish
PhD student: Susana Casado
University: Universidad Complutense de Madrid, Veterinary Faculty
Date: 20th October 2011
Director: José María Navas
Title: New insights into the toxicity of nanomaterials obtained by means of fish and mammalian cell
lines
PhD student: Tobias Lammel
University: Universidad Autónoma de Madrid, Biology Faculty
Date: 13th June 2014
Director: José María Navas
Title: Nuevos horizontes en Ecotoxicología: biomarcadores destructivos y no destructivos en codorniz
(Coturnix coturnix) y cigüeña blanca (Ciconia ciconia).
PhD student: Irene de la Casa Resino
University: Extremadura, Veterinary Faculty
Date: 20th June 2014
Directors: Marcos Pérez López, Francisco Soler Rodríguez, José María Navas
Title: Expression and function of detoxification processes in fish and alterations of reproductive
hormonal regulation
PhD student: Alba Quesada-García
University: Universidad Autónoma de Madrid, Biology Faculty
Dates: 30th October 2015
Director: Ana Valdehita García; José María Navas
Title: Mechanisms underlying the toxic action of nanomaterials: in vitro and in vivo approaches
PhD student: Mona Connolly
University: Universidad Complutense de Madrid, Facultad de Biología
Dates: To be defended in Autumn 2016
Codirectors: José María Navas and María Luisa Fernández Cruz
Title: Thyroidal activity in manure. Determination of responsible substances.
PhD student: Victor García Herranz
University: Universidad Autónoma, Programa de Doctorado en Biología
Dates: from 1rst July 2015
Codirectors: José María Navas and María Luisa Fernández Cruz