CURRICULUM VITAE Name Consuelo Borras Present post Lecturer
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CURRICULUM VITAE Name Consuelo Borras Date of birth 27 December 1976 Present post Lecturer in Nationality Spanish Physiology (04/2011- ) Work address Department of Physiology Faculty of Medicine Telephone 0034-963-864646 Fax 0034-963-864642 e-mail [email protected] University of Valencia Av. Blasco Ibanez 15 E46010 Valencia, Spain Academic Qualifications Master of Bioethics Catholic University of Valencia 09/2006-09/2008 Ph.D. Physiology Department of Physiology, University of Valencia 06/1999-11/2003 Degree in Pharmacy Faculty of Pharmacy, University of Valencia 09/1994-06/1999 Previous Academic Appointments Assistant professor University of Valencia 04/2008-04/2011 Post-doctoral Researcher Clinical Hospital of Valencia Foundation 09/2007-04/2008 Lecturer in Physiology Catholic University of Valencia 09/2005-08/2007 Superior Research Technician University of Valencia 01/2003-08/2005 Ph.D. Student (Grant from 01/2000-12/2003 University of Valencia the Ministry of Education) Honours - “Premio Extraordinario de Licenciatura” University of Valencia, 1999 - Prize for the best Ph.D. thesis “Premio Extraordinario de Doctorado” University of Valencia, 2003 - Young Investigator Award in recognition of extraordinary scientific achievements in the field of free radical research, awarded by "The Society for Free Radical Research International" Buenos Aires, 2004. -“Premio Medalla García Blanco” (2005) in recognition of research career for young investigators. - Catherine Pasquier Award (2009) by "The Society for Free Radical Research Europe" -V Award in Basic Research por La fundación para la Investigación del Hospital Clínico Universitario de Valencia (INCLIVA)(2010) Research interests Gender differences in ageing, oestrogens and phytoestrogens, extreme longevity, stem cells, Alzheimer’s disease Funded Research Grants as Principal Investigator - Generalitat Valenciana 01/2007-12/2009. Oxidative stress and diabetes: protective role of estrogens - Catholic University of Valencia. Two small grants to develop a project entitled “Phytoestrogens and up-regulation of antioxidant/longevity-related genes” - Generalitat Valenciana 07/2010-07/2011. “Study of longevity-related parameters in women treated with estradiol and progesterone after an induced-menopause” - INCLIVA 01/2013-12/2013. Intramural call: ““Study of longevity-related parameters in women treated with estradiol and progesterone after an induced-menopause” - INCLIVA 01/2015-12/2015. Intramural call: “Effect of genistein and/or bexarotene in the treatment of Alzheimer’s disease in APP/PS1 mice” - Conselleria de Sanitat APM-03/15. “Perfiles metabolómicos para la detección temprana de la fragilidad en ancianos”. - Generalitat Valenciana AICO/2016/067. “Effect of genistein and/or bexarotene in the treatment of Alzheimer’s disease in APP/PS1 mice” Funded Research Grants as Co-applicant - More than 35 research grants as co-applicant, three of them from the European Community Citation report Results found: 69 Sum of the Times Cited: 3100 Average Citations per Item: 44.93 h-index: 29 Average citations per year Five most cited papers. Average citations: 1261 - Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Viña J. Oral administration of vitamin C decreases muscle mitocondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008 Jan;87(1):142-9. (Impact factor: 6.7; 302 citations) - Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007;448(7151):375-9. (Impact factor: 34.5; 276 citations) - Borrás C, Sastre J, García-Sala D, Lloret A, Pallardó FV, Viña J. Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic Biol Med. 2003;34(5):546-52. (Impact factor: 6.1; 260 citations) - Gomez-Cabrera MC, Borrás C, Pallardó FV, Sastre J, Ji LL, Viña J. Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol. 2005 Aug 15;567(Pt 1):113-20. (Impact factor: 4.8; 230 citations) Title: Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance - Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008 Nov 14;135(4):609-22 (Impact factor: 31.2; 193 citations) Peer Reviewed Publications 1: Viña J, Tarazona-Santabalbina FJ, Pérez-Ros P, Martínez-Arnau FM, Borras C, Olaso-Gonzalez G, Salvador-Pascual A, Gomez-Cabrera MC. Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function. Mol Aspects Med. 2016 May 6. pii: S0098-2997(16)30018-8. doi: 10.1016/j.mam.2016.04.005. [Epub ahead of print] Review. PubMed PMID: 27164416. 2: Viña J, Saez GT, Gambini J, Gomez-Cabrera MC, Borrás C. Role of NAD(+)/NADH redox ratio in cell metabolism: A tribute to Helmut Sies and Theodor Bücher and Hans A. Krebs. Arch Biochem Biophys. 2016 Apr 1;595:176-80. doi: 10.1016/j.abb.2015.11.027. PubMed PMID: 27095235. 3: Santulli G, Borras C, Bousquet J, Calzà L, Cano A, Illario M, Franceschi C, Liotta G, Maggio M, Molloy WD, Montuori N, O'Caoimh R, Orfila F, Rauter AP, Santoro A, Iaccarino G. Models for preclinical studies in aging-related disorders: One is not for all. Transl Med UniSa. 2016 Jan 31;13:4-12. eCollection 2015 Dec. PubMed PMID: 27042427; PubMed Central PMCID: PMC4811343. 4: Jové M, Naudí A, Gambini J, Borras C, Cabré R, Portero-Otín M, Viña J, Pamplona R. A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans. J Gerontol A Biol Sci Med Sci. 2016 Mar 24. pii: glw048. [Epub ahead of print] PubMed PMID: 27013396. 5: Viña-Almunia J, Borras C, Gambini J, El Alamy M, Peñarrocha M, Viña J. Influence of different types of pulp treatment during isolation in the obtention of human dental pulp stem cells. Med Oral Patol Oral Cir Bucal. 2016 May 1;21(3):e374-9. PubMed PMID: 26946201; PubMed Central PMCID: PMC4867212. 6: Bonet-Costa V, Herranz-Pérez V, Blanco-Gandía M, Mas-Bargues C, Inglés M, Garcia-Tarraga P, Rodriguez-Arias M, Miñarro J, Borras C, Garcia-Verdugo JM, Viña J. Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease. J Alzheimers Dis. 2016 Feb 10;51(3):701-11. doi: 10.3233/JAD-151020. PubMed PMID: 26890773. 7: Gambini J, Gimeno-Mallench L, Inglés M, Olaso G, Abdelaziz KM, Avellana JA, Belenguer Á, Cruz R, Mas-Bargues C, Borras C, Viña J. [Identification of single nucleotide polymorphisms in centenarians]. Rev Esp Geriatr Gerontol. 2016 May-Jun;51(3):146-9. doi: 10.1016/j.regg.2015.09.006. Epub 2015 Nov 2. Spanish. PubMed PMID: 26541311. 8: Gambini J, Inglés M, Olaso G, Lopez-Grueso R, Bonet-Costa V, Gimeno-Mallench L, Mas-Bargues C, Abdelaziz KM, Gomez-Cabrera MC, Vina J, Borras C. Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans. Oxid Med Cell Longev. 2015;2015:837042. doi: 10.1155/2015/837042. Epub 2015 Jun 28. Review. PubMed PMID: 26221416; PubMed Central PMCID: PMC4499410. 9: Viña J, Inglés M, Borrás C. Response to Vidal and colleagues. J Am Geriatr Soc. 2015 Apr;63(4):838-9. doi: 10.1111/jgs.13362. PubMed PMID: 25900512. 10: Viña J, Gambini J, García-García FJ, Rodriguez-Mañas L, Borrás C. Role of oestrogens on oxidative stress and inflammation in ageing. Horm Mol Biol Clin Investig. 2013 Dec;16(2):65-72. doi: 10.1515/hmbci-2013-0039. PubMed PMID: 25436748. 11: El Alami M, Viña-Almunia J, Gambini J, Mas-Bargues C, Siow RC, Peñarrocha M, Mann GE, Borrás C, Viña J. Activation of p38, p21, and NRF-2 mediates decreased proliferation of human dental pulp stem cells cultured under 21% O2. Stem Cell Reports. 2014 Oct 14;3(4):566-73. doi: 10.1016/j.stemcr.2014.08.002. Epub 2014 Sep 18. PubMed PMID: 25358785; PubMed Central PMCID: PMC4223702. 12: Cash TP, Pita G, Domínguez O, Alonso MR, Moreno LT, Borrás C, Rodríguez-Mañas L, Santiago C, Garatachea N, Lucia A, Avellana JA, Viña J, González-Neira A, Serrano M. Exome sequencing of three cases of familial exceptional longevity. Aging Cell. 2014 Dec;13(6):1087-90. doi: 10.1111/acel.12261. Epub 2014 Aug 12. PubMed PMID: 25116423; PubMed Central PMCID: PMC4326919. 13: Inglés M, Gambini J, Carnicero JA, García-García FJ, Rodríguez-Mañas L, Olaso-González G, Dromant M, Borrás C, Viña J. Oxidative stress is related to frailty, not to age or sex, in a geriatric population: lipid and protein oxidation as biomarkers of frailty. J Am Geriatr Soc. 2014 Jul;62(7):1324-8. doi: 10.1111/jgs.12876. Epub 2014 Jun 24. PubMed PMID: 24962132. 14: Inglés M, Gambini J, Miguel MG, Bonet-Costa V, Abdelaziz KM, El Alami M, Viña J, Borrás C. PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations. Biomed Res Int. 2014;2014:580852. doi: 10.1155/2014/580852. Epub 2014 Apr 10. PubMed PMID: 24812624; PubMed Central PMCID: PMC4000926. 15: Viña JA, El-Alami M, Gambini J, Borras C, Viña J, Peñarrocha MA. Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review. J Clin Exp Dent. 2014 Feb 1;6(1):e60-5. doi: 10.4317/jced.51186. eCollection 2014 Feb. Review. PubMed PMID: 24596637; PubMed Central PMCID: PMC3935907. 16: Vina J, Borras C, Sanchis-Gomar F, Martinez-Bello VE, Olaso-Gonzalez G, Gambini J, Ingles M, Gomez-Cabrera MC. Pharmacological properties of physical exercise in the elderly. Curr Pharm Des. 2014;20(18):3019-29. Review. PubMed PMID: 24079769. 17: Viña J, Borras C, Abdelaziz KM, Garcia-Valles R, Gomez-Cabrera MC. The free radical theory of aging revisited: the cell signaling disruption theory of aging. Antioxid Redox Signal. 2013 Sep 10;19(8):779-87. doi: 10.1089/ars.2012.5111. Review. PubMed PMID: 23841595; PubMed Central PMCID: PMC3749699. 18: López-Grueso R, Gambini J, Abdelaziz KM, Monleón D, Díaz A, El Alami M, Bonet-Costa V, Borrás C, Viña J. Early, but not late onset estrogen replacement therapy prevents oxidative stress and metabolic alterations caused by ovariectomy. Antioxid Redox Signal. 2014 Jan 10;20(2):236-46. doi: 10.1089/ars.2012.5112. Epub 2013 Jul 20. PubMed PMID: 23725100; PubMed Central PMCID: PMC3887441. 19: Viña J, Borras C, Gomez-Cabrera MC. Overweight, obesity, and all-cause mortality. JAMA. 2013 Apr 24;309(16):1679. doi: 10.1001/jama.2013.3080. PubMed PMID: 23613062. 20: Gambini J, López-Grueso R, Olaso-González G, Inglés M, Abdelazid K, El Alami M, Bonet-Costa V, Borrás C, Viña J. [Resveratrol: distribution, properties and perspectives]. Rev Esp Geriatr Gerontol. 2013 Mar-Apr;48(2):79-88. doi: 10.1016/j.regg.2012.04.007. Epub 2013 Jan 15. Review. Spanish. PubMed PMID: 23332579. 21: Serna E, Gambini J, Borras C, Abdelaziz KM, Belenguer A, Sanchis P, Avellana JA, Rodriguez-Mañas L, Viña J. Centenarians, but not octogenarians, up-regulate the expression of microRNAs. Sci Rep. 2012;2:961. doi: 10.1038/srep00961. Epub 2012 Dec 11. Erratum in: Sci Rep. 2013;3:1575. Mohammed, Kheira [corrected to Abdelaziz, Kheira M]. PubMed PMID: 23233880; PubMed Central PMCID: PMC3518811. 22: Gomez-Cabrera MC, Sanchis-Gomar F, Garcia-Valles R, Pareja-Galeano H, Gambini J, Borras C, Viña J. Mitochondria as sources and targets of damage in cellular aging. Clin Chem Lab Med. 2012 Feb 1;50(8):1287-95. doi: 10.1515/cclm-2011-0795. Review. PubMed PMID: 22868792. 23: Radyuk SN, Gambini J, Borras C, Serna E, Klichko VI, Viña J, Orr WC. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Mech Ageing Dev. 2012 Jun;133(6):401-13. doi: 10.1016/j.mad.2012.04.006. Epub 2012 May 10. PubMed PMID: 22579812. 24: Vina J, Gambini J, Lopez-Grueso R, Abdelaziz KM, Jove M, Borras C. Females live longer than males: role of oxidative stress. Curr Pharm Des. 2011 Dec 1;17(36):3959-65. Review. PubMed PMID: 22188448. 25: Garcia-Garcia FJ, Gutierrez Avila G, Alfaro-Acha A, Amor Andres MS, De Los Angeles De La Torre Lanza M, Escribano Aparicio MV, Humanes Aparicio S, Larrion Zugasti JL, Gomez-Serranillo Reus M, Rodriguez-Artalejo F, Rodriguez-Manas L; Toledo Study Group. The prevalence of frailty syndrome in an older population from Spain. The Toledo Study for Healthy Aging. J Nutr Health Aging. 2011 Dec;15(10):852-6. PubMed PMID: 22159772. 26: Gambini J, Gomez-Cabrera MC, Borras C, Valles SL, Lopez-Grueso R, Martinez-Bello VE, Herranz D, Pallardo FV, Tresguerres JA, Serrano M, Viña J. Free [NADH]/[NAD(+)] regulates sirtuin expression. Arch Biochem Biophys. 2011 Aug 1;512(1):24-9. doi: 10.1016/j.abb.2011.04.020. Epub 2011 May 7. PubMed PMID: 21575591. 27: Borrás C, Gómez-Cabrera MC, Viña J. The dual role of p53: DNA protection and antioxidant. Free Radic Res. 2011 Jun;45(6):643-52. doi: 10.3109/10715762.2011.571685. Epub 2011 Mar 31. Review. PubMed PMID: 21452930. 28: Borrás C, Monleón D, López-Grueso R, Gambini J, Orlando L, Pallardó FV, Santos E, Viña J, Font de Mora J. RasGrf1 deficiency delays aging in mice. Aging (Albany NY). 2011 Mar;3(3):262-76. PubMed PMID: 21422498; PubMed Central PMCID: PMC3091520. 29: Hernandez-Mijares A, Rocha M, Apostolova N, Borras C, Jover A, Bañuls C, Sola E, Victor VM. Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients. Free Radic Biol Med. 2011 May 15;50(10):1215-21. doi: 10.1016/j.freeradbiomed.2011.01.019. Epub 2011 Jan 22. Erratum in: Free Radic Biol Med. 2015 Jul;84:386. PubMed PMID: 21262346. 30: Borrás C, Gil P, Viña J. Biogerontology in Spain: the most significant studies. Biogerontology. 2011 Feb;12(1):77-81. doi: 10.1007/s10522-010-9314-3. Epub 2010 Dec 14. Review. PubMed PMID: 21153917. 31: Caro P, Gómez J, Arduini A, González-Sánchez M, González-García M, Borrás C, Viña J, Puertas MJ, Sastre J, Barja G. Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age. Mitochondrion. 2010 Aug;10(5):479-86. doi: 10.1016/j.mito.2010.05.004. Epub 2010 May 28. PubMed PMID: 20546951. 32: López-Grueso R, Borrás C, Gambini J, Viña J. [Aging and ovariectomy cause a decrease in brain glucose consumption in vivo in Wistar rats]. Rev Esp Geriatr Gerontol. 2010 May-Jun;45(3):136-40. doi: 10.1016/j.regg.2009.12.005. Epub 2010 Mar 4. Spanish. PubMed PMID: 20206415. 33: Viña J, Borrás C. Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds. Antioxid Redox Signal. 2010 Aug 1;13(3):269-78. doi: 10.1089/ars.2009.2952. Review. PubMed PMID: 20059401. 34: Valles SL, Dolz-Gaiton P, Gambini J, Borras C, Lloret A, Pallardo FV, Viña J. Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes. Brain Res. 2010 Feb 2;1312:138-44. doi: 10.1016/j.brainres.2009.11.044. Epub 2009 Nov 27. PubMed PMID: 19948157. 35: Borrás-Blasco J, Navarro-Ruiz A, Borrás C, Casterá E. Adverse cutaneous reactions induced by TNF-alpha antagonist therapy. South Med J. 2009 Nov;102(11):1133-40. doi: 10.1097/SMJ.0b013e3181bb554c. Review. PubMed PMID: 19864977. 36: Borrás C, Gambini J, López-Grueso R, Pallardó FV, Viña J. Direct antioxidant and protective effect of estradiol on isolated mitochondria. Biochim Biophys Acta. 2010 Jan;1802(1):205-11. doi: 10.1016/j.bbadis.2009.09.007. Epub 2009 Sep 12. PubMed PMID: 19751829. 37: Viña J, Gomez-Cabrera MC, Borras C, Froio T, Sanchis-Gomar F, Martinez-Bello VE, Pallardo FV. Mitochondrial biogenesis in exercise and in ageing. Adv Drug Deliv Rev. 2009 Nov 30;61(14):1369-74. doi: 10.1016/j.addr.2009.06.006. Epub 2009 Aug 27. Review. PubMed PMID: 19716394. 38: Kireev RA, Tresguerres AC, Garcia C, Borras C, Ariznavarreta C, Vara E, Vina J, Tresguerres JA. Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomized female rats. Biogerontology. 2010 Apr;11(2):229-43. doi: 10.1007/s10522-009-9242-2. Epub 2009 Jul 26. PubMed PMID: 19633997. 39: Borrás C, Stvolinsky S, López-Grueso R, Fedorova T, Gambini J, Boldyrev A, Viña J. Low in vivo brain glucose consumption and high oxidative stress in accelerated aging. FEBS Lett. 2009 Jul 7;583(13):2287-93. doi: 10.1016/j.febslet.2009.06.019. Epub 2009 Jun 13. PubMed PMID: 19527716. 40: Matheu A, Maraver A, Collado M, Garcia-Cao I, Cañamero M, Borras C, Flores JM, Klatt P, Viña J, Serrano M. Anti-aging activity of the Ink4/Arf locus. Aging Cell. 2009 Apr;8(2):152-61. doi: 10.1111/j.1474-9726.2009.00458.x. PubMed PMID: 19239418. 41: Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008 Nov 14;135(4):609-22. doi: 10.1016/j.cell.2008.09.034. PubMed PMID: 19013273. 42: Borrás-Blasco J, Navarro-Ruiz A, Borrás C, Casterá E. Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection. J Antimicrob Chemother. 2008 Nov;62(5):879-88. doi: 10.1093/jac/dkn292. Epub 2008 Jul 23. Review. PubMed PMID: 18653488. 43: Tresguerres JA, Kireev R, Tresguerres AF, Borras C, Vara E, Ariznavarreta C. Molecular mechanisms involved in the hormonal prevention of aging in the rat. J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):318-26. doi: 10.1016/j.jsbmb.2007.09.010. Epub 2007 Sep 7. PubMed PMID: 18252241. 44: Viña J, Sastre J, Pallardó FV, Gambini J, Borrás C. Modulation of longevity-associated genes by estrogens or phytoestrogens. Biol Chem. 2008 Mar;389(3):273-7. doi: 10.1515/BC.2008.027. Review. PubMed PMID: 18177268. 45: Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Viña J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008 Jan;87(1):142-9. PubMed PMID: 18175748. 46: Vallés SL, Borrás C, Gambini J, Furriol J, Ortega A, Sastre J, Pallardó FV, Viña J. Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38. Aging Cell. 2008 Jan;7(1):112-8. Epub 2007 Nov 21. PubMed PMID: 18031570. 47: Viña J, Gomez-Cabrera MC, Borras C. Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation? Br J Nutr. 2007 Oct;98 Suppl 1:S36-40. Review. PubMed PMID: 17922957. 48: Viña J, Lloret A, Vallés SL, Borrás C, Badía MC, Pallardó FV, Sastre J, Alonso MD. Effect of gender on mitochondrial toxicity of Alzheimer's Abeta peptide. Antioxid Redox Signal. 2007 Oct;9(10):1677-90. Review. PubMed PMID: 17822363. 49: Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007 Jul 19;448(7151):375-9. PubMed PMID: 17637672. 50: Viña J, Lloret A, Vallés SL, Borrás C, Badía MC, Pallardó FV, Sastre J, Alonso MD. Mitochondrial oxidant signalling in Alzheimer's disease. J Alzheimers Dis. 2007 May;11(2):175-81. Review. PubMed PMID: 17522442. 51: Viña J, Borrás C, Miquel J. Theories of ageing. IUBMB Life. 2007 Apr-May;59(4-5):249-54. Review. PubMed PMID: 17505961. 52: Markovic J, Borrás C, Ortega A, Sastre J, Viña J, Pallardó FV. Glutathione is recruited into the nucleus in early phases of cell proliferation. J Biol Chem. 2007 Jul 13;282(28):20416-24. Epub 2007 Apr 23. PubMed PMID: 17452333. 53: Borras C, Gambini J, Vina J. Mitochondrial oxidant generation is involved in determining why females live longer than males. Front Biosci. 2007 Jan 1;12:1008-13. Review. PubMed PMID: 17127355. 54: Viña J, Sastre J, Pallardó FV, Gambini J, Borrás C. Role of mitochondrial oxidative stress to explain the different longevity between genders: protective effect of estrogens. Free Radic Res. 2006 Dec;40(12):1359-65. Review. PubMed PMID: 17090425. 55: Borrás C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV, Mann GE, Viña J. Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB. FASEB J. 2006 Oct;20(12):2136-8. Epub 2006 Sep 11. PubMed PMID: 16966488. 56: Vina J, Borras C, Gomez-Cabrera MC, Orr WC. Part of the series: from dietary antioxidants to regulators in cellular signalling and gene expression. Role of reactive oxygen species and (phyto)oestrogens in the modulation of adaptive response to stress. Free Radic Res. 2006 Feb;40(2):111-9. Review. PubMed PMID: 16390819. 57: Mahn K, Borrás C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP, Sharpe RM, Viña J, Aaronson PI, Mann GE. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J. 2005 Oct;19(12):1755-7. Epub 2005 Aug 17. PubMed PMID: 16107535. 58: Viña J, Borrás C, Gambini J, Sastre J, Pallardó FV. Why females live longer than males: control of longevity by sex hormones. Sci Aging Knowledge Environ. 2005 Jun 8;2005(23):pe17. Review. PubMed PMID: 15944465. 59: Gomez-Cabrera MC, Borrás C, Pallardó FV, Sastre J, Ji LL, Viña J. Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol. 2005 Aug 15;567(Pt 1):113-20. Epub 2005 Jun 2. PubMed PMID: 15932896; PubMed Central PMCID: PMC1474177. 60: Borrás C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV, Mann GE, Viña J. 17beta-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade. Aging Cell. 2005 Jun;4(3):113-8. PubMed PMID: 15924567. 61: Viña J, Borrás C, Gambini J, Sastre J, Pallardó FV. Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. FEBS Lett. 2005 May 9;579(12):2541-5. Epub 2005 Apr 14. Review. PubMed PMID: 15862287. 62: Sastre J, Martín JA, Gómez-Cabrera MC, Pereda J, Borrás C, Pallardó FV, Viña J. Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis. Free Radic Biol Med. 2005 Mar 1;38(5):575-82. PubMed PMID: 15683713. 63: Borrás C, Esteve JM, Viña JR, Sastre J, Viña J, Pallardó FV. Glutathione regulates telomerase activity in 3T3 fibroblasts. J Biol Chem. 2004 Aug 13;279(33):34332-5. Epub 2004 Jun 7. PubMed PMID: 15184392. 64: Serviddio G, Pereda J, Pallardó FV, Carretero J, Borras C, Cutrin J, Vendemiale G, Poli G, Viña J, Sastre J. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology. 2004 Mar;39(3):711-20. PubMed PMID: 14999689. 65: Viña J, Sastre J, Pallardó F, Borrás C. Mitochondrial theory of aging: importance to explain why females live longer than males. Antioxid Redox Signal. 2003 Oct;5(5):549-56. Review. PubMed PMID: 14580309. 66: Borrás C, Sastre J, García-Sala D, Lloret A, Pallardó FV, Viña J. Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic Biol Med. 2003 Mar 1;34(5):546-52. PubMed PMID: 12614843. 67: Sastre J, Lloret A, Borrás C, Pereda J, García-Sala D, Droy-Lefaix MT, Pallardó FV, Viña J. Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver. Cell Mol Biol (Noisy-le-grand). 2002 Sep;48(6):685-92. Review. PubMed PMID: 12396080. 68: Shaban H, Borrás C, Viña J, Richter C. Phosphatidylglycerol potently protects human retinal pigment epithelial cells against apoptosis induced by A2E, a compound suspected to cause age-related macula degeneration. Exp Eye Res. 2002 Jul;75(1):99-108. PubMed PMID: 12123641. 69: Sastre J, Borrás C, García-Sala D, Lloret A, Pallardó FV, Viña J. Mitochondrial damage in aging and apoptosis. Ann N Y Acad Sci. 2002 Apr;959:448-51. PubMed PMID: 11976217. Ph.D. Supervisor - Juan Gambini “Efecto del estradiol y otros compuestos estrogénicos sobre la expresión de genes asociados a la longevidad”, July 2007 - Raul Lopez Grueso “Importancia del inicio de la terapia hormonal sustitutiva sobre el consumo cerebral de glucosa”, 2010 - Ana Díaz Cuevas “Estrés oxidativo y diabetes: papel protector de los estrógenos”, 2011 - Marya El Alami “Obtención de células madre de la pulpa dental. Caracterización y adaptación a diversas condiciones de oxígeno”, 2013 - Kheira Mohamed Abdelaziz “Efecto del consumo de soja sobre la longevidad de ratones OF1 machos”, 2013 - Francisco Vicente Bonet Costa “Estudio del estres oxidativo hepatico asociado a la enfermedad de alzheimer. Efecto del tratamiento con bexaroteno y / o genisteina”, 2013 - José Viña Almunia “Obtencion y caracterizacion de celulas madre de pulpa dental humanas e interaccion con β-fosfato tricalcico”, 2014 - Marta Ingles De La Torre “Identificacion de biomarcadores de fragilidad en el estudio de toledo de envejecimiento saludable”, 2014 - Consuelo Escrivá López “Estudio de los valores de referencia para los parámetros de estrés oxidativo malondialdehído y glutatión, medidos por cromatografía líquida de alta eficacia, en humanos y animales de experimentación”, 2016 Invited Seminars and Talks Over 60 invited talks or selected as oral communications at national and international conferences and academic institutions including: The Physiological Society, London; University of California, Davis; European Standards Committee on Oxidative DNA Damage, Valencia; Gender Medicine Congress, Rome; International Conference on Food Factors for Health Promotion -ICoFF2007, Kyoto; Grupo Español de Radicales Libres; Sociedad Española de Geriatria y Gerontologia; Sociedad Española de Medicina Antienvejecimiento y Longevidad; Sociedad Española de Bioquímica y Biología Molecular, Sociedad Española de Medicina Geriátrica, Universidad de Valencia, Universidad Autónoma de Barcelona, Universidad Complutense de Madrid, Colegio de Farmacéuticos de la Región de Murcia, Ministerio de Ciencia y Tecnología. Symposium and Meeting Organisation - Young Physiology Symposium, Seville Feb 2005 - XXXV Congress of the Spanish Society of Physiological Sciences - SFRR Europe Summer School 2014 edition Editorial tasks - Member of the PLoS One editorial board - Member of the Oxidative Medicine and Cellular Longevity editorial board - Member of Nutrition and food science, official journal of Nutrition And Food Science External Reviewing Experience - Grants: Reviewer of German-Israeli Foundation for Scientific Research and Development (GIF), Agencia Nacional De Colombia, - Publications: Reviewer for scientific journals including: British Journal Of Nutrition, Cancer Chemotherapy And Pharmacology, Journal Of Diabetes And Its Complications, Drug, Healthcare And Patient Safety, European Journal Of Nutrition, Gerontology, Journal Of Women's Health, Journal Of Neurochemistry, Mechanisms Of Ageing And Development, Plos One, Experimental Gerontology, Free Radical Research, Apoptosis, BBA - Bioenergetics (Els), Cancer Chemotherapy And Pharmacology, Experimental Dermatology, Free Radical Biology And Medicine, Journal Of Bioscience And Bioengineering, Journal Of Cellular And Molecular Medicine, Neuropharmacology, Revista Española De Geriatria Y Gerontologia, Age, Antioxidants, Redox Biology - PhD Examiner: Participation in thesis viva voce examinations for Ph.D. candidate in the University of La Laguna (Tenerife), University of Extremadura and University of Valencia Committees - European Society for Free Radical Research council member - Biological section spokesperson of the Geriatric and Gerontological Spanish Society - Free radical group coordinator of the Society for Biochemistry and Molecular Biology - COST CM1001 member Hobbies - Classical music - Sharing time with my family Dr. Borras can provide documents to prove all the statements included in this CV
