SEYLE FINAL REPORT 1. Executive Summary Saving and Empowering Young Lives in Europe (SEYLE) is a randomized controlled trial (RCT) aimed at promoting mental health among adolescents in European schools. The SEYLE project was performed during January 2009 – December 2011, and comprised a consortium of 12 European countries: Austria, Estonia, France, Germany, Hungary, Ireland, Israel, Italy, Romania, Slovenia and Spain, with Sweden serving as the coordinating centre. Its main objectives were to gather information on health and well-being in European adolescents; to lead adolescents to better mental health through decreased risk-taking and suicidal behaviours; evaluate outcomes of different preventive programmes; and recommend effective culturally-adjusted models for promoting adolescent mental health in different European countries. Epidemiological results SEYLE generated a large epidemiological database containing information regarding sociodemographics, other risk factors, lifestyles, and the mental health of adolescents in Europe. The database contains information regarding 366 variables for 12,395 cases, for a total of over 4.5 million observations. The analysis of this database is still in progress and the data will be used for several studies in coming years. Preliminary prevalence regarding psychopathology, such as depressive and anxiety symptoms, hyperactivity, suicidal ideation and behaviour and lifestyles such as substance abuse, including alcohol, smoking and illegal drugs; sleep, nutrition and physical activity, and; Internet use is available Outcome results Longitudinal analysis has identified improvements following SEYLE interventions in several mental health outcomes. Depressive symptoms in the whole sample significantly decreased in all RCT arms at 3 months follow-up, with a further significant decrease observed at the 12 months follow-up. The most important and novel results of the SEYLE research study are found when examining effects on suicide attempts. At 3 and 12 months follow-ups, a significant and sustainable decrease in suicide attempters was present in the Awareness arm in comparison with the control group. At the 12 months follow-up evaluation, a significant decrease in the number of those who attempted suicide in the previous two weeks was observed among pupils in the QPR and Profscreen arms. Impact of SEYLE and recommendations The scientific and societal impact of these findings from SEYLE study are highly relevant. As previously noted, risk behaviours and mental health problems among adolescents are a serious public health concern. The longitudinal results of SEYLE revealed important effects of the interventions on the studied mental health related outcomes. These findings support a series of recommendations regarding interventions for mental health promotion among adolescents. The Awareness program had a significant influence on suicide attempts in both the short and the long term. The program also significantly increased adolescent well-being. This program was well accepted by both pupils and school staff. It is, therefore, our recommendation that a mental health and suicide preventive Awareness program be included in the syllabi of schools across Europe. It would be important to determine at which ages this would be most efficacious. The SEYLE results regarding the Professional Screening arm call for public mental health actions, as 12·4% of the adolescents were identified as being in need of mental healthcare. Attention to risk-behaviours, in addition to psychopathology, is critical in facilitating prevention and early intervention. Screening in schools for both risk-behaviour and psychopathology can be a valuable approach in detecting students with psychological problems that require mental healthcare. Strategies designed to increase compliance with clinical interviews are needed to improve the value of screening procedures. Even if the feasibility of a large scale screening program can be problematic, as revealed by lower than expected participation rates to this arm’s follow-up interviews, screening programs certainly have excellent value as a means of assessing mental health needs and well-being in school-based populations. The QPR intervention designed to ttrain teachers to recognize and support students at risk, also demonstrated efficacy for certain outcomes. The most striking finding regarding teachers’ role in the life of adolescents is their interest and opportunity to take action to improve students’ mental health and well-being. Our conclusions and recommendations are that teachers in European schools, in general, are able to identify the most severe symptoms of mental disorders in their students, but the observed level of mental health literacy is currently not adequate to fulfil their gatekeeper role; teachers recognize their lack of knowledge and skills related to child mental health and expresses a desire to be better educated in this area; mental health literacy differs significantly among the eleven European countries; information about mental health should be included in the teachers’ educational curriculum. Analysis of the SEYLE Control arm, where a minimal intervention including a component of the Awareness program was implemented, yielded some important results concerning emotional symptoms. Even though the effects of the minimal intervention were significantly smaller and appeared to be shorter in duration, the fact that an effect was present deserves attention and suggests that a simple awareness increasing intervention can also be important. On the other hand the minimal intervention had no effect on suicide attempts, which are an important predictive factor for completed suicide and the most serious outcome of mental ill-health. Even if, from an economical point of view a minimal intervention could be recommended, especially in settings where funds are limited, a longer and more structured intervention is necessary in order to obtain positive outcomes regarding suicidal behaviour among adolescents. 1 | P a g e