Acoplamiento de Reacciones
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Acoplamiento de Reacciones Juan Pablo Damián Bioquímica –Curso BMC – 2009 Facultad de Veterinaria pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! ATP: moneda energética universal en todas las células • La hidrólisis del ATP per se normalmente no consigue nada excepto la liberación de calor. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! ATP: moneda energética universal en todas las células • La hidrólisis del ATP per se normalmente no consigue nada excepto la liberación de calor. ATP, puede transferir energía desde compuestos fosfato de alta energía producidos en el catabolismo hasta compuestos de baja energía, convirtiéndolos en especies más reactivas. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Una reacción termodinámicamente desfavorable (endergónica) puede ser posible? pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Una reacción termodinámicamente desfavorable (endergónica) puede ser posible? Sí, gracias al acoplamiento de reacciones pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Una reacción termodinámicamente desfavorable (endergónica) puede ser posible? Sí, gracias al acoplamiento de reacciones secuenciales a través de un intermediario común. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! 6 ATP CH2OH ADP 6 H 4 OH 5 H OH 3 H H Mg2+ 4 OH 2 HEXOQUINASA OH OH H OH 3 H Glucosa (G) H 1 OH 2 OH Glucosa 6 Fosfato (G6P) G + Pi Compuesto rico en energía 5 H 1 CH2OPO3= G6P + H2O ATP + H2O ADP + Pi G + ATP G6P + ADP G´= 13,8 kJ/mol G´= - 30.5 kJ/mol G´= - 16.7 kJ/mol Fosforila la glucosa para las reacciones que tienen lugar en casi todas las células. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! … hasta compuestos de baja energía como la glucosa… 6 ATP CH2OH ADP 6 H 4 OH 5 H OH 3 H H Mg2+ 1 4 OH 2 HEXOQUINASA OH OH 5 H OH 3 H Glucosa (G) H 2 1 OH OH Glucosa 6 Fosfato (G6P) G + Pi Compuesto rico en energía H CH2OPO3= ATP + H2O G + ATP G6P + H2O G´= 13,8 kJ/mol ADP + Pi G´= - 30.5 kJ/mol G6P + ADP G´= - 16.7 kJ/mol pdfMachine Is a pdf that producesque qualitytienen PDF files with ease!en casi todas las células. cebaProduce la glucosa para laswriter reacciones lugar quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Glucosa+ Pi Glucosa 6-P + H2O ∆G’°= 13.8 kJ/mol El carácter aditivo de los ∆G permite que una reacción endergónica sea dirigida por una reacción exergónica bajo las condiciones adecuadas. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Glucosa+ Pi Glucosa 6-P + H2O ATP + H2O ADP + Pi pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! ∆G’°= 13.8 kJ/mol ∆G’°= - 30.5 kJ/mol Glucosa+ Pi Glucosa 6-P + H2O ATP + H2O ADP + Pi pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! ∆G’°= 13.8 kJ/mol ∆G’°= - 30.5 kJ/mol Las ∆G’° son aditivas Glucosa+ Pi Glucosa 6-P + H2O ATP + H2O ADP + Pi Glucosa + ATP Glucosa 6-P + ADP ∆G’°= 13.8 kJ/mol ∆G’°= - 30.5 kJ/mol ∆G’°= - 16.7 kJ/mol La reacción global es exergónica Los de cambios de energía libre son aditivos y permiten que una reacción endergónica sea impulsada por una reacción exergónica bajo condiciones apropiadas. Las dos reacciones están acopladas por medio de su intermediario común. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! El ATP cómo se sintetiza? -O O ADP ATP -O O C C 1 H C 2 3 1 OPO3= CH2 C 2 PIRUVATO KINASA 3 Fosfoenolpiruvato (PEP) CH3 Piruvato (PIR) PEP +H2O Compuesto muy rico en energía O ADP + Pi Pi + PIR ATP +H2O PEP + ADP PIR + ATP G´= - 61.9 kJ/mol G´= + 30.5 kJ/mol G´= - 31.4 kJ/mol pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! ÄG´° de hidrólisis (kJ/mol) Fosfoenolpiruvato Fosfocreatina 1,3-Bisfosfoglicerato -25 KJ/mol pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Compuestos de alta energía Compuestos de baja energía Síntesis del ATP -O O ADP C C 2 3 -O O C Mg+2 K+ 1 H ATP 1 OPO3= CH2 C 2 PIRUVATO KINASA 3 Fosfoenolpiruvato (PEP) CH3 Piruvato (PIR) PEP +H2O Compuesto muy rico en energía O ADP + Pi Pi + PIR ATP +H2O PEP + ADP PIR + ATP G´= - 61.9 kJ/mol G´= + 30.5 kJ/mol G´= - 31.4 kJ/mol pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! ATP transfiere energía desde compuestos muy ricos en energía hasta… -O O ADP ATP -O O C C 1 H C 2 3 1 OPO3= CH2 C 2 PIRUVATO KINASA 3 Fosfoenolpiruvato (PEP) CH3 Piruvato (PIR) PEP +H2O Compuesto muy rico en energía O ADP + Pi Pi + PIR ATP +H2O PEP + ADP PIR + ATP G´= - 61.9 kJ/mol G´= + 30.5 kJ/mol G´= - 31.4 kJ/mol pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! … hasta compuestos de baja energía como la glucosa… 6 ATP CH2OH ADP 6 H 4 OH 5 H OH 3 H H Mg2+ 4 OH 2 HEXOQUINASA OH OH H OH 3 H Glucosa (G) H 2 1 OH OH Glucosa 6 Fosfato (G6P) G + Pi Compuesto rico en energía 5 H 1 CH2OPO3= G6P + H2O ATP + H2O ADP + Pi G + ATP G6P + ADP G´= 13,8 kJ/mol G´= - 30.5 kJ/mol G´= - 16.7 kJ/mol pdfMachine Is a pdf that producesque qualitytienen PDF files with ease!en casi todas las células. cebaProduce la glucosa para laswriter reacciones lugar quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! … hasta compuestos de baja energía como la glucosa… 6 ATP CH2OH ADP 6 H 4 OH 5 H OH 3 H H Mg2+ 1 4 OH 2 HEXOQUINASA OH OH 5 H OH 3 H Glucosa (G) H 2 1 OH OH Glucosa 6 Fosfato (G6P) G + Pi Compuesto rico en energía H CH2OPO3= ATP + H2O G + ATP G6P + H2O G´= 13,8 kJ/mol ADP + Pi G´= - 30.5 kJ/mol G6P + ADP G´= - 16.7 kJ/mol pdfMachine Is a pdf that producesque qualitytienen PDF files with ease!en casi todas las células. cebaProduce la glucosa para laswriter reacciones lugar quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! EJERCICIO Consideren estas dos reacciones de la Glucólisis: 1) GAP + NAD+ + Pi 1,3BPG + NADH + H+ ÄGº’ = + 6.3 kJ.mol-1 2) 1,3-BPG + ADP 3-PG + ATP ÄGº’ = -18.8 kJ.mol-1 La suma de las dos reacciones es : GAP + NAD+ +ADP + Pi 3PG + NADH + H+ + ATP ÄGº’ = ÄGº’1 + ÄGº’2 = + 6.3 + ( -18.8) = -12.5 kJ.mol -1 pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! EJERCICIO Consideren estas dos reacciones de la Glucólisis: 1) GAP + NAD+ + Pi 1,3BPG + NADH + H+ ÄGº’ = + 6.3 kJ.mol-1 2) 1,3-BPG + ADP 3-PG + ATP ÄGº’ = -18.8 kJ.mol-1 La suma de las dos reacciones es : GAP + NAD+ +ADP + Pi 3PG + NADH + H+ + ATP ÄGº’ = ÄGº’1 + ÄGº’2 = + 6.3 + ( -18.8) = -12.5 kJ.mol -1 pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! • • • • Responder ¿Qué compuestos ricos en energía intervienen? ¿Son reacciones acopladas? ¿Cuál es el reactivo intermediario común? ¿Qué compuesto se sintetiza, consumiendo energía? pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Soluciones 1,3BPG y ATP Es un caso de acoplamiento de reacciones El intermediario común es el 1,3BPG Se oxida el GAP a expensas del NAD+, que se reduce • Se sintetiza ATP a partir de ADP y Pi • • • • pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Características de las reacciones acopladas Implican la ruptura de enlaces ricos en energía del ATP o de derivados fosforilados de azúcares. Son bastante comunes en las rutas metabólicas y generalmente implican la transferencia de grupos fosforilo. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Acoplamiento de reacciones • El carácter aditivo de los ∆G permite que una reacción endergónica sea dirigida por una reacción exergónica bajo las condiciones adecuadas. • Este fenómeno es la base termodinámica del metabolismo celular. pdfMachine Is a pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now!