! " # & $ !"#% ' ()* * & + & , -./0 ' ()* * Dedicado a Laura y Alejandro Agradecimientos Quiero expresar mi más sincero agradecimiento a todas las personas que, de una u otra forma, han contribuido a que este trabajo sea una realidad, de forma muy especial: Al Dr. Alfonso Valencia, por la aceptación para la realización del máster y por brindar la oportunidad de realizar las prácticas en un sitio del nivel del CNIO. A la Dra. Fátima Al-Shahrour, por la oportunidad de realizar las prácticas en su grupo de investigación, así como por su continuo asesoramiento y ayuda prestada en todo momento. A mis compañeros de la Unidad de Bioinformática Translacional del CNIO, por la buena acogida, el buen ambiente de trabajo y por su buena predisposición para ayudar en cualquier momento. A los compañeros del CNIO con los que he tenido la suerte de coincidir durante mi estancia, por el buen ambiente mostrado en todo momento. A mis compañeros de máster, por fomentar siempre el buen compañerismo tanto durante los estudios como los buenos ratos que hemos pasado juntos fuera. A Luis Pérez del Villar porque, aunque nos dejaste pronto tu memoria permanecerá viva entre nosotros. A Laura Mínguez, por ser mi compañera y por robarle tiempo para dedicarlo a este proyecto, así como por su enorme paciencia para soportar mis divagaciones sobre genómica, perl y machine learning. A mi hijo Alejandro, que vino al mundo durante la realización de este proyecto, por ser el mejor "proyecto" al que es posible aspirar y por lograr que su sonrisa, me hiciera más llevadera cualquier dificultad durante la realización del trabajo. ! % " # $ & ' ( ))*+,-* . / 0 . 1 ' ( 1 23 4 0 ' ( 1 5 " $ " 6 ) 6 7 ) $ " 8 9 " & ' ( 6 ) 6 6. : " & " " . . ) " & . . . . ' ( . . " . : ))*+,-* ; 6 " 5 . . !"#$% &# ' (& !)'*' + !' - + 7 # = > ? > < 5 < : # & < > @ > 8 ? 2 " 9 > A < B * 8 7 & @ D > ? : 9< # 5 C ? 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