DEGRADACIÓN DE ISOLEUCINA, LEUCINA Y VALINA

α descarboxilación
H2N
COOH
COOH
C
C
H
CH
CH2
H3C
CH3
CH3
H3C CH2 CH C
CH3
+
NAD
H2O
O
O
CH
CH2
H3C
FADH2
FAD
H3C CH CH C
C
H3C CH C
SCoA
CH3
OH CH
3
CH3 C
COOH
COOH
C
C
H
CH
H 3C
CH3
H 3C
SCoA
C
CH C
O
CH3
SCoA
HSCoA
Ileu
H 2N
+
O
O
O
SCoA
NADH + H
FAD
descarboxilación
CH
H 3C
CH3
CH3CH C
CH3
H2C
C
C
H3C
CH2C
SCoA
β descarboxilación
oxidación
O
O
SCoA
O
SCoA
H2O
FADH2
O
O
O
H 2C
SCoA
CH C
SCoA
OH CH3
CH3
O
O
C
HO
CH C
CH3
SCoA
Val
CH3 C
DEGRADACIÓN DE ISOLEUCINA,
LEUCINA Y VALINA
H3C
C
O
SCoA
OH
CH2 COOH
HOOC
O
H2N
C
C
H
CH2
H3C
CH
CH3
Leu
O
CH
CH3
H3C
FAD
FADH2
O
H3C
CH CH2 C
CH3
SCoA
CH3
α descarboxilación
CH2
O
C CH2 C
H3C
COOH
SCoA
SCoA
CH3
OH
COOH
O
CH2 C CH2 C
H 3C
CO2
H2O
H2O
O
C CH C
SCoA
CH3
O
HOOC CH2 C
CH3
CH C
SCoA