Complicaciones del tratamiento y de la propia infección

Complicaciones de la infección por el VIH
y envejecimiento
Eugènia Negredo
Fundació Lluita contra la Sida
Hospital Universitari Germans Trias i Pujol
Barcelona
Març 2016
CARDIOVASCULAR e INFLAMACIÓN
ü  Mayor riesgo infarto (NA-CCORD vs MESA)
ü  Abacavir
ü  Ecuaciones ACC/AHA vs ATP III vs DAD vs Framingham
ü  Activación inmune
125.-­‐ Immunopathogenesis of Metabolic Complica:ons in Treated HIV Infec:on Suzanne M. Crowe 44LB.-­‐ Aspirin Fails to Impact Immune Ac:va:on or Endothelial Func:on in Treated HIV Meagan K. O’Brien 41.-­‐ Early An:retroviral Therapy Does Not Improve Vascular Func:on: A START Substudy Jason V. Baker 123.-­‐ Visceral Adiposity in the Modern HIV Treatment Era Grace A. McComsey STROKE
43.-­‐ Stroke Incidence Highest in Women and Black HIV-­‐Infected Par:cipants in ALLRT Cohort Felicia Chow 638.-­‐ Persistently Increased Ischemic Stroke Risk in HIV-­‐Infected Women Felicia Chow ALTERACIONES ÓSEAS
46.-­‐ An:retrovirals, Fractures, and Osteonecrosis in a Large European HIV Cohort Alvaro H. Borges 699.-­‐ Fractures Occur at a Younger Age in HIV+ Men in the Mul:center AIDS Cohort Study Anda R. Gonciulea; Todd T. Brown HIV –infected and HIV unifectected men (MACS cohort) 47.-­‐ A Single Dose Zoledronic Acid Prevents An:retroviral-­‐Induced Bone Loss Ighovwerha Ofotokun 48.-­‐ Mineral Density Ader Stopping Oral HIV Preexposure Prophylaxis Robert Grant 126 What Exactly Does An:retroviral Therapy Do to Bone? Patrick Mallon ALTERACIONES RENALES
683.-­‐ Longer-­‐Term Renal Safety of Tenofovir Alafenamide vs Tenofovir Disoproxil Fumarate Bart J. Rijnders Discon:nua:ons for renal events: -­‐ 6 pa&ents on E/C/F/TDF -­‐ No pa&ents on E/C/F/TAF 680.-­‐ Longer-­‐Term Safety of Tenofovir Alafenamide in Renal Impairment Frank A. Post Orange-­‐ preswitch TDF Without preswitch TDF Five discon&nua&ons due to renal adverse events: -­‐  All of them HTA (4/5 uncontrolled or poorly controlled) -­‐  No evidence of tubulopaty ENVEJECIMIENTO Y FRAGILIDAD
670.-­‐ Risk Factors of Short Telomere Length and Decreased Mitochondrial DNA in HIV Pa:ents Rumi Minami 719.-­‐ Frailty Is Associated With NNRTI-­‐Based Ini:al ART and Modifiable Risks in ACTG 5322 Kris:ne M. Erlandson ACTG 5322 or HAILO study Muchas Gracias